Global Journal of Biotechnology and Biomaterial Science
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The solution of crystallization problem was introduced around twenty years ago, with the introduction of crystallization screening methods.
Volume 2 Issue 1 - 2016
Open Access
Article Type: Research Article
Biomaterial and Regenerative Medicine Approaches to Restoration of Flexion in Lumbar Herniated Disc
Objective: The systematic objective of this paper is to restore flexion in vertebral bone and to nourish the nucleus pulposus through the approach of biomaterial and regenerative medicine.
Open Access
Article Type: Mini Review
Nano-Technological Approaches to Improve the Efficiency of Bio-Assays
One of the biggest issues in today's healthcare industry is to find a very fast yet effective diagnostic platform, which is suitable for our busy lifestyle without compromising the detection efficiency.
Open Access
Article Type: Research Article
Ruta graveolens Protects Against Isoniazid/Rifampicin-Induced Nephrotoxicity through Modulation of Oxidative Stress and Inflammation
Background and Aim: Drug-induced nephrotoxicity is a renal dyfunction that arises as a result of exposure to nephrotoxic drugs. Anti-tuberculosis therapy can cause nephrotoxicity and permanent kidney damage. The current study was designed to evaluate the possible protective effects of Ruta graveolens L. leaves extract against isoniazid/rifampicin-induced nephrotoxicity in rats.
Methods: The experimental rats received isoniazid and rifampicin at dose level of 50 mg/kg, and 50 or 100 mg/kg/day Ruta graveolens leaves extract orally for 45 days.
Open Access
Article Type: Research Article
Optimization of Sintering Conditions for Improvement of Mechanical Property of α-Tricalcium Phosphate Blocks
Bioactive ceramic materials have been under research as bone substitute for several decades. To repair the high-load bearing bones, mainly cortical bones, there is a need for the substitute to possess comparable mechanical strength to cortical bone, of which the compressive strength ranges between 100 and 230 MPa. Two prevailing bone repairing material, β-tricalcium phosphate (β-TCP, β-Ca3(PO4)2) and hydroxyapatite (HAp: Ca10(PO4)6(OH)2) have been widely researched and sintered into dense blocks to meet the mechanical requirements.
Volume 1 Issue 1 - 2015
MicroRNAs (miRNAs) are a family of short non-coding RNA molecules which contain about 18-24 nucleotides. miRNAs play significant regulatory roles in biological processes (cell proliferation, differentiation, survival and motility).
Most aquatic and health management authorities need assessing the potential genotoxicity of contaminated effluent to avoid the effects of a lot chemical agents found as environmental contaminants. Previous studies report the presence of some pesticides and heavy metals in waters of Santiago River and suggest a genetic risk for residents, who lived nearby this river, so it is important determine its mutagenic risk.
Open Access
Article Type: Short Communication
Consumption of Aloe vera Mucilage Attenuates Plasma Oxidative Stress and Dyslipidemia in Type 2 Diabetic Rats
This study found that Aloe vera mucilage administration significantly improved biological parameters including lipids composition and oxidative stress in type 2 diabetic rats. Because the mRNA levels of lipogenic genes were significantly down-regulated (P<0.01) by the intervention of A. vera mucilage, this improvement of these biological parameters may be caused, at least in part, by the regulation of hepatic genes that are involved in lipids metabolism, thus resulting in an increase of cholesterol clearance and β-oxidation as well as a reduction of hepatic lipogenesis. The results in this study might provide a further beneficial effect of A. vera mucilage in the possible management of dyslipidemia-related diseases.
