Open Access Research Article Article ID: ADA-2-112

    Electrophysiological Profiling of Depression in the Elderly

    Jenny L Patterson, J. Bruce Barber, Daniel W. O Connor and Samia R Toukhsati

    Frontostriatal system functioning has been  proposed to underpin  performance on executive functioning tasks; these structures are abnormally activated in adults with depression. In this study, the P200 and P300 event-related potentials (ERPs) were elicited during a classic two-tone auditory oddball task to compare the electrophysiological profiles of elderly people (N = 54; Mean age = 85.46 ± 6.21) diagnosed with clinical depression ( n  = 17), subthreshold depression ( n  = 25) or no depression ( n  = 12). The P200 results revealed higher amplitude and significantly longer latencies in depressed groups relative to non-depressed  participants. Higher P300 amplitude, but shorter latencies, were observed  in depressed relative to non-depressed participants.  Findings  are  discussed  in  terms  of cognitive information processing models of ERPs and the potential for non-cognitive factors to impact on the resulting electrophysiological profile.


    Published on: Jul 23, 2016 Pages: 31-36

    Full Text PDF Full Text HTML DOI: 10.17352/2455-5460.000012
    CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat


    Case Reports

    Pinterest on ADA

    Help ? Google Reviews 11