Biomaterial and Regenerative Medicine Approaches to Restoration of Flexion in Lumbar Herniated Disc

R Leela*

Objective- The systematic objective of this paper is to restore flexion in vertebral bone and to nourish the nucleus pulposus through the approach of biomaterial and regenerative medicine.

Method- Studies were made on the treatment of lumbar herniated disc in CINAHIL, PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL) and Cochrane Database of Systematic Reviews(CDSR). This paper provides methods for restoration of flexion in the bone. A biomaterial scaffold made of poly-β-hydroxybutyrate (PHB) consisting of extracellular matrix (ECM)  proteins which is synthesized in vitro through regenerative medicine is replaced in the place of degenerated disc. The scaffold model is designed in CAD and then printed in LAB. The metabolic functions of the disc are performed by the scaffold.

Results- Fifteen papers, published between 2004 and 2014 were included in this study. Disc height restoration is possible using biomaterial and tissue engineering but none of the papers provide reports on flexion of the bone. The treatment of non-operative modalities like physical therapy, antiinflammatory medications and steroid injections still results in low back pain. The surgical methods like Joint arthroplasty and non-fusion techniques spare motion but not restore normal spine biomechanics.The study shows that the treatment with cells and biomaterials shows better results.

Conclusion- Both the non-operative and surgical methods do not provide a good result. They donot offer flexion in the bone. The use of biomaterial scaffolds with ECM proteins paves a way for the medical professionals to treat lumbar herniated disc.

Keywords: Flexion; Nucleus pulposus; Biomaterial scaffold; Poly-β-hydroxybutyrate; Regenerative; Medicine; Extracellular matrix

Published on: Sep 16, 2016 Pages: 19-24

Full Text PDF Full Text HTML DOI: 10.17352/gjbbs.000007
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