Open Access Review Article Article ID: GJODMS-5-132

    Obesity, Diabetes and Gastrointestinal Malignancy: The role of Metformin and other Anti-diabetic Therapy

    Michael Ashamalla, Irini Youssef, Mena Yacoub, Apoorva Jayarangaiah, Nikita Gupta, Justina Ray, Sadat Iqbal, Regina Miller Joie Singh and Samy I McFarlane*

    The association between Diabetes and cancer has been known for decades with obesity and insulin resistance being postulated as the main underlying risk factors for both disorders. With rise of the epidemic of obesity in the USA and around the globe, there has been a rise in diabetes that is currently reaching epidemic proportions. Diabetes is known to be associated with increased risk of several types of malignancy including breast, cervical, pancreatic and colon cancer. In this review, we discuss the epidemic of obesity and its consequential epidemic of diabetes highlighting the pathophysiologic mechanisms of increased cancer in the diabetic population. We will then discuss the role of insulin therapy as well as other antidiabetic medications, particularly metformin that has been to be associated with lower risk as well as better survival with GI malignancies based on several studies including a study that was recently published by our group.

    Keywords: Gastrointestinal malignancy; Colon cancer; Diabetes; Obesity; Insulin resistance; Metformin; Insulinsensitizers

    Published on: Jul 27, 2018 Pages: 8-14

    Full Text PDF Full Text HTML DOI: 10.17352/2455-8583.000032
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