Open Access Research Article Article ID: JFSNT-3-109

    Serum levels of Vitamin A and Atopic Rhinoconjunctivitis in Swedish adolescents

    Malin Barman*, Nils-Gunnar Carlsson, Anna Sandin, Agnes E. Wold and Ann-Sofi e Sandberg

    Aim: Vitamin A plays a role in mucosal immunity and tolerance, but the association between vitamin A status and allergy is still unclear. The aim of the study was to analyze the levels of vitamin A in serum from adolescents with or without atopic rhinoconjunctivitis.

    Method: Thirteen-year-old children with atopic rhinoconjunctivitis (n = 53) and non-allergic, nonsensitized controls (n = 52) were randomly selected from a population based prospective birth cohort comprising 1228 children in Northern Sweden born in 1996-1997. Vitamin A (retinol) concentrations in serum were measured with high performance liquid chromatography mass spectrometry. Multiple logistic regression was used to evaluate the association between allergy prevalence and serum vitamin A levels.

    Results: Multiple logistic regression analysis showed no association between serum vitamin A levels and atopic rhinoconjunctivitis prevalence; OR = 1.00 (95% confidence interval 1.00-1.00), p = 0.81.       Stratification for gender revealed a trend for a higher risk for having atopic rhinoconjunctivitis with higher concentrations of vitamin A in serum for females, OR = 1.02 (1.00-1.05), p = 0.07. No such associations were found in male subjects OR = 0.99 (0.97-1.01), p = 0.15. A dose-response relationship between allergy and vitamin A concentrations were also calculated but no such relationships were found, neither for all subjects nor for male and females separately.

    Conclusions: Serum levels of vitamin A could neither be positively nor negatively associated with atopic rhinoconjunctivitis in Swedish teenagers.

    Keywords: Atopic rhinoconjunctivitis; Retinol; Vitamin A

    Published on: Sep 12, 2017 Pages: 14-19

    Full Text PDF Full Text HTML DOI: 10.17352/jfsnt.000009
    CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat


    Case Reports

    Pinterest on JFSNT

    Help ? Google Reviews 11