2026-05-14T02:23:15Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/2455-1759.000021 2016-07-15 PTZ.AOR:VOL2

Outcomes following total Laryngectomy for Squamous Cell Carcinoma at a Singapore Tertiary Referral Centre Wei Zhong Ernest Fu Ming Yann Lim Jeevendra KanagalingamChristopher GL Hobbs<p><strong>Objectives:</strong> To evaluate the clinical outcomes and complications following total laryngectomy in a South-East Asian Population.&nbsp;</p><p><strong>Design:</strong> 10-year retrospective review of cases of total laryngectomy or laryngo-pharygectomy.&nbsp;</p><p><strong>Main&nbsp; outcome measures:</strong> 5-year overall survival (OS) and disease-free survival (DFS).</p><p><strong>Results:</strong> 61 patients of which 55 (90%) had laryngeal SCC while 6 (10%) had hypopharyngeal SCC. Overall&nbsp; edian survival was 85 months. 5-year OS and DFS for laryngeal SCC were 65% and 47%&nbsp; respectively while 5-year OS and DFS for hypopharyngeal SCC were both 33%. Most common cause of&nbsp; death was due to advanced cancer secondary to disease recurrence.</p><p><strong>Conclusion:</strong> Although there is increasing tendency towards laryngeal preservation, surgery remains a safe treatment option for selected patients with laryngeal and hypopharyngeal SCC. In our local population,&nbsp; patients often present late with advanced cancer, as demonstrated by the high rate of emergency reoperative tracheostomy. However, there is no evidence that this affects survival.</p> Archives of Otolaryngology and Rhinology - Peertechz Publications 2016-07-15 Research Article https://doi.org/10.17352/2455-1759.000021 en Copyright © Wei Zhong Ernest Fu et al.