2026-06-03T17:09:21Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/2455-2283.000003 2015-07-27 PTZ.ACG:VOL1

The Effect on Gastric Emptying of Telaprevir-Based Triple Therapy for Chronic Hepatitis C Patients Arata Oyamada Makoto Arai Tomoaki Matumura Kenichiro Okimoto Shoko Minemura Keiko Saito Daisuke Maruoka Tomoo Nakagawa Tatsuo Kanda Tatsuro KatsunoOsamu Yokosuka<p><strong>Aim: </strong>We evaluated food intake in telaprevir-based triple therapy (telaprevir, pegylated-interferon, and ribavirin) and its relation to Gastric Emptying (GE). <br></p><p><strong>Methods: </strong>17 patients received telaprevir combined with pegylated interferon plus ribavirin. The GE study was carried out using the 13C-acetate breath test and GE time was expressed as the peak time of 13CO2 excretion (Tmax). <br></p><p><strong>Results:&nbsp; </strong>The average food intake was 1,851 ± 91, 1,338 ± 537 and 1,453 ± 537 kcal at 0, 1, and 2 weeks after the start of treatment, respectively, showing a significant decrease compared to that before treatment (p &lt; 0.01 and p &lt;0.05, paired t-test). The averages of Tmax values at 0, 1, and 2 weeks after the start of treatment were 48.4 ± 14.3 min, 56.9 ± 18.4 min and 58.0 ± 19.9 min, respectively. There was a significant difference between baseline and 1 week after the start of treatment (p&lt;0.05, paired t-test). Food intake (kcal) showed a good correlation with the decrease of Tmax values (minutes) (Pearson’s correlation test, r = -0.49, p &lt; 0.05).&nbsp;</p><p><strong>Conclusions: </strong>Telaprevir-based triple therapy caused reduced food intake and worsened GE.</p> Archives of Clinical Gastroenterology - Peertechz Publications 2015-07-27 Research Article https://doi.org/10.17352/2455-2283.000003 en Copyright © Arata Oyamada et al.