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oai:www.peertechzpublications.org:10.17352/2455-3484.000004 2015-01-04 PTZ.JAMTS:VOL1

Reward Deficiency Solution System &#40;RDS&#41;: A Tale of Three Scientists Kenneth Blum Rajendra D Badgaiyan Mark S Gold<p>Prior to 1990 there was a paucity of studies directed at psychiatric genetics and in fact there was only one study by Egeland et al. [1]. whereby an analysis of the segregation of restriction fragment length polymorphisms (RFLP) in an Old Order Amish population (pedigree) localized a dominant gene linked to a strong predisposition to manic depressive disease to chromosome 11 possibly tyrosine hydroxylase.</p><p>This finding was retracted in 1989 by Kelsoe et al. [2]. Following these very early studies Blum and Noble and their respective groups reported on the first ever confirmed association of the dopamine D2 receptor gene (DRD2) and severe alcoholism [3]. While this sparked some controversy [4] it was confirmed [5] and remains the most widely studied gene in psychiatric genetics and lead to the development of an entire field of medicine (PubMed 8/8/14- 14,661) –<strong>known as Psychiatric Genetics.</strong></p> Journal of Addiction Medicine and Therapeutic Science - Peertechz Publications 2015-01-04 Editorial https://doi.org/10.17352/2455-3484.000004 en Copyright © Kenneth Blum et al.