2026-05-30T17:28:37Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/2455-3484.000013 2016-04-30 PTZ.JAMTS:VOL2

Risks of Methadone use as Substitute Therapy for Opioid Addiction during Pregnancy and use of Clonidine as a Plausible Alternative Masroor Munim Zafar Iqbal David F Stowe<p>The prevalence of illicit opiate use during pregnancy along with other substances has been increasing [1,2]. The prevalence of opioid abuse or dependence during pregnancy increased from 0.17% in 1998</p><p>to 0.39% in 2011 for an increase of 127% [3]. There is firm evidence that pregnancy outcome is worse in women using opiates than in the general population [1,4,5]. Deliveries associated with maternal opioid</p><p>abuse or dependence compared with those without opioid abuse or dependence were associated with an increased odds (adjusted odds ratio) of maternal death during hospitalization, cardiac arrest, intrauterine growth restriction, placental abruption, length of stay more than 7 days, preterm labor, oligohydramnios, transfusion, stillbirth, premature rupture of membranes, and cesarean delivery [3]. Another problem for about 50% of neonates of opioid-addicted mothers is development of neonatal abstinence syndrome (NAS) requiring opiate treatment for opioid withdrawal after birth [6,7].</p> Journal of Addiction Medicine and Therapeutic Science - Peertechz Publications 2016-04-30 Review Article https://doi.org/10.17352/2455-3484.000013 en Copyright © Masroor Munim et al.