2026-04-10T23:57:38Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/2455-3786.000006 2014-12-18 PTZ.JHCSR:VOL1

Development of Mucoadhesive Gel Microbicide to Target Mucosal HIV Reservoirs Ranjita ShegokarKamalinder K Singh<p>The wide use of microbicide is mainly depends on its effectiveness, less frequent application,</p><p>ready availability and most importantly cost. The aim of this work was to develop affordable microbicide</p><p>mucoadhesive gel formulation of synthetic anti HIV drug, stavudine and to characterise it in terms</p><p>of its physical properties, mucoadhesiveness and spreadability. The purpose of the present study</p><p>was also to compare different dissolution media used for in vitro release of vaginal dosage form. The</p><p>gels were tested for antimicrobial, spermicidal and anti-HIV activity. Gels prepared using Carbopols</p><p>and Polycarbophil were transparent and homogenous and had excellent mucoadhesion index - and</p><p>showed fast drug release profile. Gels showed very good antimicrobial action against pathological</p><p>microorganism.</p> Journal of HIV for Clinical and Scientific Research - Peertechz Publications 2014-12-18 Research Article https://doi.org/10.17352/2455-3786.000006 en Copyright © Ranjita Shegokar et al.