2026-05-21T21:23:54Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/2455-3786.000036 2023-11-16 PTZ.JHCSR:VOL10

Sonographic appearances of the kidneys and correlation with CD4 count and viral load in adult HIV/AIDS patients in a rural-based infectious disease hospital in sub-saharan Africa Ehi-Imuse AJ Adeyekun AA Irabor PFI Azubike COIzevbekhai SO<p>Background: The management of HIV infection is often challenging as it can affect every organ in the body including the kidneys. Determination of the Resistivity Indices (RI) of the intra-renal arteries is an emerging non-invasive tool that could predict renal disease.&nbsp;</p><p>Aims &amp; objectives: To determine the renal volume, parenchymal pattern, as well as the RI of the intra-renal arteries by Doppler ultrasonography in adult HIV/AIDS patients and correlate findings with CD4 count, viral load and serum creatinine.</p><p>Materials &amp; methods: This is a comparative cross-sectional descriptive study that involved sonographic assessment of the renal dimensions, parenchymal echogenicity, and Doppler velocimetry of the segmental intra-renal arteries in 100 apparently healthy confirmed HIV-seronegative control subjects and an equal number of confirmed HIV-seropositive adult patients at Retroviral (RV) clinic of our hospital. A Doppler ultrasound machine with a 3.5MHz Curvilinear probe was used.&nbsp;</p><p>Data analysis: Data obtained was analyzed and presented as means which were compared using Student’s t - test, and p values &lt; 0.05 at 95% intervals were considered significant. Pearson’s correlation coefficient was used to assess correlation.</p><p>Results: The renal volumes were larger in the HIV/AIDS subjects (right: 125.94 ± 34.02 cm3 and left: 138.99 ± 33.29cm3) than in controls (p = &lt; 0.01) with the left also larger than the right in both HIV/AIDS and control subjects (p = &lt; 0.01, &lt; 0.01) respectively.&nbsp;</p><p>There were significantly more individuals with abnormal renal echogenicity in the HIV/AIDS subjects than in the controls.</p><p>The RI was significantly greater in the HIV/AIDS than in control subjects.</p><p>&nbsp;Both renal volumes showed a weak negative correlation with CD4, viral load, and serum creatinine which was not statistically significant.&nbsp;</p><p>There was a statistically significant weak negative correlation between renal echogenicity and CD4 but a positive correlation with viral load and serum creatinine.&nbsp;</p><p>RI showed weak negative correlations with serum creatinine and weak positive correlations with CD4 count.&nbsp;</p><p>Conclusion: There is a significant difference in renal volume, echogenicity, and RI in HIV/AIDS patients compared to the controls. Renal echogenicity is a better predictor of serum creatinine levels than renal volume and RI. Thus, renal volume and RI do not provide sufficient correlation to be used as a means of monitoring HIV/AIDS patients with renal impairment.</p> Journal of HIV for Clinical and Scientific Research - Peertechz Publications 2023-11-16 Research Article https://doi.org/10.17352/2455-3786.000036 en Copyright © Ehi-Imuse AJ et al.