2026-05-29T16:03:49Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/2455-5363.000018 2018-08-28 PTZ.GJIDCR:VOL4

Meta-Analysis of Risk Factors for Development of Liver Cirrhosis in Chronic Hepatitis B Patients Gaofeng Cai Yongdi Chen Li Li Biao Zhou Chonggao Hu Yanhong Yu Mengxin Xu Qiaolu Hong Zhengting Wang Kui Liu Zhifang Wang Zhenggang JiangJun Yao<p>Chronic hepatitis B virus (HBV) infection and chronic hepatitis C virus (HCV) are main reasons for the development of liver cirrhosis (LC) on a worldwide scale. Chronic HBV infection is a main reason for the development of LC in high-risk areas, for example, China and Africa, whereas chronic HCV infection is a main reason in developed countries. In China, the harm of LC is serious, and 30 million of chronic hepatitis B (CHB) patients is the major source of LC and the one-year cumulative incidence rate of LC in CHB patients was 2.1% - 6%. The risk factors of the development of LC in CHB patients reported were controversial.&nbsp;</p><p>Therefore, we took CHB as participants, and we searched for studies in Chinese Medical Journal Database, Pubmed, Elsevier, Springer, Wiley, OVID, and EBSCO via BoKu data service platform, and did a meta-analysis and evaluated whether those published risk factors changed the development risk of LC. Both odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CI) were calculated by Review Manager 5.0.</p><p>In this meta-analysis, 2928cases and 6530controls from 29 studies were analyzed. The pooled OR with 95% CI for 5 factors analyzed were: drinking alcohol 1.32 (1.11, 1.59), cigarette smoking 1.26 (1.04, 1.52), hepatitis B e antigen (HBeAg) seropositivity 0.42 (0.19, 0.94), a family history of hepatitis B 1.95 (1.05, 3.62), and male gender 1.33 (1.08, 1.65), respectively. And the pooled MD with 95% CI for 6 factors analyzed were: serum aspartate aminotransferase/alanine aminotransferase (AST/ALT ) ratio 0.29(0.18,0.39), serum total bilirubin (TBil) levels 8.25(5.58,10.92)umol/L, duration of hepatitis B 2.68(2.21,3.15) years, age 7.37(4.60,10.14)years, serum alpha fetoprotein (AFP) levels -0.91(-16.04,14.22)ug/L, and serum HBV DNA levels 0.37 (-0.28, 1.02)copies/ml, respectively.&nbsp;</p><p>In CHB patients, habits of drinking alcohol and cigarette smoking, elevated serum levels of TBil and serum AST/ALT ratio, increased duration of hepatitis B, a family of hepatitis B, male gender and older age can increase the risk of LC development.</p> Global Journal of Infectious Diseases and Clinical Research - Peertechz Publications 2018-08-28 Research Article https://doi.org/10.17352/2455-5363.000018 en Copyright © Gaofeng Cai et al.