2026-05-30T09:41:22Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/2455-5460.000012 2016-07-23 PTZ.ADA:VOL2

Electrophysiological Profiling of Depression in the Elderly Jenny L Patterson J. Bruce Barber Daniel W. O ConnorSamia R Toukhsati<p>Frontostriatal system functioning has been&nbsp; proposed to underpin&nbsp; performance on executive functioning tasks; these structures are abnormally activated in adults with depression. In this study, the P200 and P300 event-related potentials (ERPs) were elicited during a classic two-tone auditory oddball task to compare the electrophysiological profiles of elderly people (N = 54; Mean age = 85.46 ± 6.21) diagnosed with clinical depression ( n&nbsp; = 17), subthreshold depression ( n&nbsp; = 25) or no depression ( n&nbsp; = 12). The P200 results revealed higher amplitude and significantly longer latencies in depressed groups relative to non-depressed&nbsp; participants. Higher P300 amplitude, but shorter latencies, were observed&nbsp; in depressed relative to non-depressed participants.&nbsp; Findings&nbsp; are&nbsp; discussed&nbsp; in&nbsp; terms&nbsp; of cognitive information processing models of ERPs and the potential for non-cognitive factors to impact on the resulting electrophysiological profile. </p> Archives of Depression and Anxiety - Peertechz Publications 2016-07-23 Research Article https://doi.org/10.17352/2455-5460.000012 en Copyright © Jenny L Patterson et al.