2026-05-29T15:20:29Z
https://www.peertechzpublications.org/oai-pmh
oai:www.peertechzpublications.org:10.17352/2455-5495.000003
2015-08-03
PTZ.ARDM:VOL1
Clinical Significance of Hilar Hyalinosis in Glomeruli of Children with Idiopathic Nephrotic Syndrome
Amal AAl-EisaThomas M D’souza<p><strong>Introduction:</strong> Hilar hyalinosis (HH) of glomeruli has been thought for a long time to be a precursor or a variant of focal glomerulosclerosis (FGS). In view of its implications on treatment and prognosis of nephrotic syndrome, a retrospective study of hilar hyalinosis in children with the idiopathic nephrotic syndrome (INS), but without any other histologic evidence of FGS, was performed to determine the clinic-pathologic significance of this lesion.</p><p><strong>Methods: </strong>A total of 92 Children with INS who had kidney biopsies for frequent relapses, steroid dependency or resistance were included. Eight of them had a biopsy-proven diagnosis of either minimal change disease or mild IgM nephropathy with HH in 6-25% of glomeruli were compared to control group consisting of 84 children with either minimal change disease (n=57) or IgM nephropathy (n=27) but without HH.</p><p><strong>Results:</strong> Clinically HH patients presented with NS and followed a steroid-dependent relapsing course prior to biopsy. Around 75% of the HH patients received at least one course of cytotoxic therapy after biopsy. At last visit, 6 patients were in remission, 2 were protein-free but on medication. None had hypertension or renal insufficiency. Apart from having a shorter interval between presentation and biopsy (P<0.001) and a lower remission rate (P<0.05), control patients followed a similar course.Pathologically HH patients showed less mesangial change (P<0.001) than the controls but similar mean glomerular size and tubuloinerstitial damage.</p>
Archives of Renal Diseases and Management - Peertechz Publications
2015-08-03
Research Article
https://doi.org/10.17352/2455-5495.000003
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