2026-06-03T20:39:43Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/2455-5495.000011 2016-07-16 PTZ.ARDM:VOL2

Does Acute Kidney Injury Alter Energy Metabolism of Septic Patients? Ana Cláudia Soncini Sanches Cassiana Regina de Góes Marina Nogueira Berbel Bufarah André Luis BalbiDaniela Ponce<p><strong>Background:</strong> The&nbsp; determination&nbsp; of&nbsp; resting&nbsp; energy&nbsp; expenditure&nbsp; (REE)&nbsp; in&nbsp; critically&nbsp; ill&nbsp; patients&nbsp; is essential to prevent hypo and hyper alimentation. </p><p><strong>Objectives: </strong>This study aims to describe the REE in septic patients with and without acute kidney injury (AKI) and compare by examining the REE estimated by Harris-Benedict equation (HB) with the REE measured by indirect calorimetry (IC).</p><p><strong>Methods:</strong> Prospective study was performed in septic patients older than 18 years, undergoing mechanical ventilation, with or without AKI defined by KDIGO criteria, and admitted to the Intensive Care Unit of University Hospital. The REE was estimated by HB equation and measured by IC within 72 hours after the diagnosis of sepsis and seven days after the initial measure. </p><p><strong>Results: </strong>Sixty-eight&nbsp; patients&nbsp; were&nbsp; evaluated,&nbsp; age&nbsp; was&nbsp; 62.49±16.6&nbsp; years,&nbsp; 63.2%&nbsp; had&nbsp; AKI,&nbsp; and SOFA was 9.81±2.35. The measured REE was 1857.53±685.32 kcal, while the estimated REE was 1514.87±356.72&nbsp; kcal,&nbsp; with&nbsp; adequacy&nbsp; of&nbsp; 123.49±43%.&nbsp; Septic&nbsp; patients&nbsp; without&nbsp; AKI&nbsp; (n=25)&nbsp; and&nbsp; with AKI&nbsp; (n=43)&nbsp; had&nbsp; measured&nbsp; REE&nbsp; statistically&nbsp; higher&nbsp; than&nbsp; the&nbsp; estimated&nbsp; one&nbsp; (1855&nbsp; kcal&nbsp; (1631.75-2052.75)&nbsp; vs.&nbsp; 1551&nbsp; kcal&nbsp; (1349&nbsp; -1719.25),&nbsp; p=0.007&nbsp; and&nbsp; 1868.0&nbsp; kcal&nbsp; (1219.5-2364.75)&nbsp; vs.&nbsp; 388&nbsp; kcal(1254-1665.5), p=0.026, respectively). There was no significant difference between the two groups in measured and estimated REE and in evolutional REE.</p> Archives of Renal Diseases and Management - Peertechz Publications 2016-07-16 Research Article https://doi.org/10.17352/2455-5495.000011 en Copyright © Ana Cláudia Soncini Sanches et al.