2026-06-09T20:29:35Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/2455-5495.000016 2016-12-09 PTZ.ARDM:VOL2

Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposition: Report of Two Cases and Review of Literature Renu Mariam Thomas<p>Here we report two cases of proliferative glomerulonephritis with monoclonal IgG deposits, a form of renal involvement by monoclonal gammopathy that mimics immune complex glomerulonephritis. Case 1 presented with incidental proteinuria and a renal biopsy showed mesangioproliferative glomerulonephritis with monoclonal IgG kappa deposits on immunofluorescence examination. He remains stable after one year follow up. Case 2 presented with rapidly progressive renal failure and renal biopsy showed rescentic membranoproliferative glomerulonephritis with monoclonal IgG kappa deposits on immunofluorescence study.&nbsp; He&nbsp; showed&nbsp; no&nbsp; response&nbsp; to&nbsp; aggressive&nbsp; immunosuppressive&nbsp; medication&nbsp; and&nbsp; plasmapheresis&nbsp; and remained&nbsp; anuric.&nbsp; He&nbsp; underwent&nbsp; renal&nbsp; transplantation&nbsp; three&nbsp; months&nbsp; later&nbsp; but&nbsp; disease&nbsp; recurred&nbsp; in&nbsp; the allograft,&nbsp; which&nbsp; was&nbsp; diagnosed&nbsp; on&nbsp; a&nbsp; biopsy&nbsp; one&nbsp; and&nbsp; a&nbsp; half&nbsp; months&nbsp; post-transplant.&nbsp; Extensive&nbsp; work&nbsp; up for&nbsp; underlying&nbsp; paraprotein&nbsp; disease&nbsp; was&nbsp; negative&nbsp; in&nbsp; both&nbsp; patients.&nbsp; Our&nbsp; aim&nbsp; is&nbsp; to&nbsp; expand&nbsp; awareness&nbsp; and highlight the heterogeneity in the clinical presentation, histology and outcome of this rare entity. </p> Archives of Renal Diseases and Management - Peertechz Publications 2016-12-09 Case Report https://doi.org/10.17352/2455-5495.000016 en Copyright © Renu Mariam Thomas et al.