2026-04-05T12:54:29Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/2455-5495.000017 2017-05-03 PTZ.ARDM:VOL3

Short-Term Effects of Pre/Probiotics on P-Cresol and Indoxyl-Sulphate Serum Concentrations During the Various Stages of Chronic Kidney Disease Filomena Panza Diletta Duranti Ralli Chiara Matteo Basile Marco Bagnati Giorgio BellomoEnnio Duranti<p><strong>Background:</strong>The&nbsp; uremic&nbsp; syndrome&nbsp; is&nbsp; provoked&nbsp; by&nbsp; a&nbsp; progressive&nbsp; number&nbsp; of&nbsp; compounds&nbsp; that&nbsp; are&nbsp; normally&nbsp; excreted&nbsp; by&nbsp; kidneys&nbsp; in&nbsp; healthy&nbsp; individuals.&nbsp; Indoxylsulphate&nbsp; (IXS)&nbsp; and&nbsp; p-cresylsulphate&nbsp; (PCS), have&nbsp; been&nbsp; found&nbsp; increased&nbsp; in&nbsp; subjects&nbsp; with&nbsp; end&nbsp; stage&nbsp; renal&nbsp; disease&nbsp; (ESRD)&nbsp; creating&nbsp; great&nbsp; harm&nbsp; to biological&nbsp; systems;&nbsp; these&nbsp; uremic&nbsp; toxins&nbsp; come&nbsp; from&nbsp; the&nbsp; intestinal&nbsp; bacterial&nbsp; fermentation&nbsp; of&nbsp; the&nbsp; proteins.The aim of our study is to evaluate the short-term effects after an administration of pre / probiotics in CKD patients, regarding the production and then the serum concentrations of free IXS and PCS (i.e. non-protein bound fraction) and total IXS and PCS ( i.e. sum of unbound and protein bound fraction).</p><p><strong>Methods:</strong> In our study , 26 patients with CKD stage 2-5 associated with hypertension and / or diabetes mellitus type 2 were enrolled, and administered with 2 g/day dose of pre-probiotics for four months: mixed oligofructose&nbsp; (prebiotic&nbsp; component)&nbsp; +&nbsp; Lactobacillus&nbsp; acidophilus&nbsp; and&nbsp; Bifidobacterium&nbsp; longum (probiotic component). In all patients, at the beginning of the study, kidney function tests, glucose metabolism, PTH and blood uric acid were evaluated. Free and total PCS and IXS were also measured. 20 control subjects with normal renal function were considered in relation to the same parameters.</p><p>After&nbsp; 4&nbsp; months&nbsp; 19&nbsp; patients&nbsp; were&nbsp; re-evaluated&nbsp; in&nbsp; relation&nbsp; to&nbsp; the&nbsp; same&nbsp; parameters.&nbsp; Statistical&nbsp; differences were studied using the Student-t paired and unpaired tests.</p> Archives of Renal Diseases and Management - Peertechz Publications 2017-05-03 Research Article https://doi.org/10.17352/2455-5495.000017 en Copyright © Filomena Panza et al.