2026-06-09T20:29:13Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/2455-5495.000024 2017-06-26 PTZ.ARDM:VOL3

Effects of Anabolic Androgenic Steroids on Renal Morphology in Rats Virginia A Aparicio Daniel Camiletti-Moirón Mohammed Tassi Elena Nebot Carlos de- TeresaPilar Aranda<p><strong>Aim:</strong> To&nbsp; investigate the long-term effects of anabolic androgenic steroids (AAS)&nbsp; on renal status in rats.</p><p><strong>Methods: </strong>Twenty Wistar rats were distributed into 2 groups: AAS or placebo, for 3 months.The animal received 10mg/kg body weight of Stanozonol once a week by intramuscular injection in the gluteus, or saline solution as placebo. </p><p><strong>Results:</strong> Urinary&nbsp; pH&nbsp; was&nbsp; more&nbsp; acidic&nbsp; in&nbsp; the&nbsp; AAS&nbsp; compared&nbsp; to&nbsp; the&nbsp; placebo&nbsp; group&nbsp; (p&lt;0.05).&nbsp; Kidney weight was 15% higher in the AAS compared to the placebo group (p&lt;0.001). Renal glomerular area was 12% higher in the AAS compared to the placebo group (p=0.001). Animals injected with AAS also displayed a no significant but clinically relevant ~20% higher kidney interstitial connective tissue, glomerular tufts and mesangiums.</p><p><strong>Conclusion: </strong>Overall, AAS negatively affected urinary pH and kidney morphology leading to a worse renal status. More attention should be taken to the use of AAS among populations at high risk for kidney disease.</p> Archives of Renal Diseases and Management - Peertechz Publications 2017-06-26 Research Article https://doi.org/10.17352/2455-5495.000024 en Copyright © Virginia A Aparicio et al.