2026-06-09T20:28:37Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/2455-5495.000030 2017-09-26 PTZ.ARDM:VOL3

Persistent hypocomplementemia in a 9 year old boy following acute poststreptococcal glomerulonephritis Ali Derakhshan<p>Acute&nbsp; post-streptococcal&nbsp; glomerulonephritis&nbsp; (APSGN)&nbsp; is&nbsp; a common&nbsp; form&nbsp; of&nbsp; acute glomerulonephritis&nbsp; in&nbsp; children&nbsp; [1].&nbsp; It is&nbsp; presented&nbsp; with&nbsp; edema,&nbsp; hematuria,&nbsp; acute&nbsp; renal&nbsp; failure&nbsp; and hypertension and hypocomplementemia 7-10days following agroup&nbsp; a -hemolytic&nbsp; streptococcal&nbsp; pharyngitis&nbsp; or&nbsp; 2-4&nbsp; weeks following an impetigo [2-4]. Subclinical forms are common in close&nbsp; contacts&nbsp; [5-7].&nbsp; APSGN&nbsp; usually&nbsp; is&nbsp; a&nbsp; self-limiting&nbsp; disease and&nbsp; only&nbsp; requires&nbsp; conservative&nbsp; therapy&nbsp; for&nbsp; complications&nbsp; of acute&nbsp; kidney&nbsp; injury&nbsp; and&nbsp; also&nbsp; management&nbsp; of&nbsp; hypertension. Severe&nbsp; cases&nbsp; may&nbsp; occur&nbsp; with&nbsp; a&nbsp; rapidly&nbsp; progressive&nbsp; course (rapidly progressive glomerulonephritis RPGN) [8], which may need&nbsp; kidney&nbsp; biopsy&nbsp; and&nbsp; pulse&nbsp; therapy&nbsp; with&nbsp; corticosteroids. Alternate pathway activation and depression of C3 is the usual mechanism&nbsp; but&nbsp; in&nbsp; some&nbsp; cases&nbsp; there&nbsp; may&nbsp; be&nbsp; activation&nbsp; of classic&nbsp; pathway&nbsp; [4].&nbsp; C3&nbsp; Complement&nbsp; returns&nbsp; to&nbsp; normal&nbsp; level within 8 weeks. In our case despite a usual feature APSGN and spontaneous&nbsp; resolution&nbsp; of&nbsp; nephritis&nbsp; C3&nbsp; is&nbsp; still&nbsp; low&nbsp; even&nbsp; after 5.5 years.</p> Archives of Renal Diseases and Management - Peertechz Publications 2017-09-26 Case Report https://doi.org/10.17352/2455-5495.000030 en Copyright © Ali Derakhshan et al.