2026-05-25T00:34:43Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/2455-8605.000032 2019-07-20 PTZ.IJDCR:VOL5

Low PD-1 expression and no prognostic impact in early-stage Mycosis Fungoides: 61 patients retrospective cohort analysis Gustavo Moreira Amorim123 Danielle Carvalho Quintella1 João Paulo Niemeyer Corbellini1 Luiz Claudio Ferreira4 Marcia Ramos-e-Silva12Tullia Cuzzi124<p><strong>Background</strong>: Mycosis fungoides (MF) is an indolent behavior cutaneous T-cell lymphoma. Most patients present a slowly progressive course, over many years. However, some patients evolve early towards advanced stages of the disease, despite adequate treatment, having therefore, a worse prognosis. Increasing knowledge of risk factors that contribute to a better prognostic evaluation is considered of interest.</p><p><strong>Aims</strong>: Evaluate positivity and prognostic importance of PD-1 marker in early-stage MF. <strong><br></strong></p><p><strong>Methods</strong>: Retrospective cohort study with early-stage MF patients. Cases were defi ned by Pimpinelli criteria. PD-1 positivity was tested in complementary immunohistochemistry over the fi rst skin biopsies done in our hospital. Disease progression, death and MF-related death was investigated 5 years after the date of the diagnostic defi nition according to the proposed criteria. The hazard ratio was calculated as association measurement. Adopted signifi cance criterion was 5%.</p> International Journal of Dermatology and Clinical Research - Peertechz Publications 2019-07-20 Research Article https://doi.org/10.17352/2455-8605.000032 en Copyright © Gustavo Moreira Amorim1 et al.