2026-04-24T14:37:17Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/aaa.000003 2018-01-17 PTZ.AAA:VOL2

Thiolutin Derivatives as inhibitor of RNA-Dependent RNA Polymerase (RdRP) of Hepatitis C Virus: An In-silico Approach Muhammad Imran Qadir Asma Munawar Syed Bilal Hussain<p>Docking study of few Thiolutin derivatives, which originally act as Hepatitis C Virus RNA Dependent RNA Polymerase (RdRP) inhibitor, was performed by using AutoDock Vina. The docking studies reveal that thiolutin interacted with Hepatitis C Virus RNA Dependent RNA Polymerase through hydrogen bonding as well as hydrophobic interactions. Its binding energy after modification (Thiolutin1) was -6.7 kcal/mol, which was greater than the original thiolutin affinity.</p> Annals of Antivirals and Antiretrovirals - Peertechz Publications 2018-01-17 Research Article https://doi.org/10.17352/aaa.000003 en Copyright © Muhammad Imran Qadir et al.