2026-05-10T13:01:22Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/aaa.000017 2023-06-13 PTZ.AAA:VOL7

Clinical presentation, ICU management and outcome in severe COVID-19 disease – A prospective observational study Prakash Shastri<p>Aim: We conducted a prospective, observational study to describe the clinical characteristics, management, and outcomes of patients with moderate to severe coronavirus disease admitted to the Intensive Care Unit (ICU).</p><p>Methods: The study was conducted from 1st July 2020 to 31st December 2020. The criteria for ICU admission included a positive Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) for the novel Coronavirus (SARS-CoV-2) and oxygen saturation of less than 90% with or without oxygen.&nbsp;</p><p>Results: A total of 621 patients were included (median age, 59 years [interquartile range {IQR}, 48-68]; 75.8% were males. The common comorbidities were hypertension (323 [52%]), and diabetes mellitus. 96 (15.5%) patients underwent mechanical ventilation, 18 (2.9%) received renal replacement therapy, and 223 (36%) died. The median age in non-survivors was significantly higher [63 years (IQR 55-71)] vs. 57 years (IQR 46-66)] (p &lt; 0.001). Hypoxia (oxygen saturation (SpO2 &lt; 90%) and shortness of breath suggestive of impending respiratory failure were the most common symptoms necessitating ICU admission. A low absolute lymphocyte count (ALC), and high levels of inflammatory biomarkers which persisted for seven days after diagnosis were significantly associated with non-survival. Multivariate logistic regression analysis showed shortness of breath (SOB), hypoxia (SpO2 &lt; 90% on oxygen), use of neuromuscular blockers, and chronic kidney disease as independent risk factors associated with mortality as were the severity scores (APACHE and SOFA).&nbsp;</p><p>Conclusion: This single-center case series provides clinical characteristics and outcomes of patients with confirmed COVID-19 disease admitted to the COVID ICU. These findings are important for guiding research and preparing for future pandemics.</p> Annals of Antivirals and Antiretrovirals - Peertechz Publications 2023-06-13 Research Article https://doi.org/10.17352/aaa.000017 en Copyright © Prakash Shastri et al.