2026-05-03T04:14:35Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/aadc.000004 2017-07-17 PTZ.AADC:VOL1

Citicoline in Vascular Cognitive Impairment: Some Latest Evidences Pietro GareriAlberto Castagna<p>CDP-choline (cytidine-5′-diphosphate choline), also called citicoline, is one of the most frequently pre scribed drugs for cognitive impairment in several European countries and worldwide [1–3].</p><p>In clinical practice, a number of different studies have shown that citicoline is effective in Parkinson’s disease, glaucoma, amblyopia, head trauma and cognitive impairment (CI) of diverse etiology, such as in CI following cerebrovascular disease [1-4].</p><p>Citicoline is able to inhibit apoptosis associated with cerebral isch emia and several models of neurodegeneration [1–3]. It can also potentiate neuroplasticity and is a natural precursor of phosphatidylcholine, one of the most important structural phospholipids in the neuronal membranes.Furthermore, since it is formed by choline, it works for biosynthesis of acetylcholine [1–3], CDP-choline increases cerebral metabolism, noradrenaline, and dopamine levels in the cen tral nervous system (CNS) [1,4].</p> Annals of Alzheimer's and Dementia Care - Peertechz Publications 2017-07-17 Short Communication https://doi.org/10.17352/aadc.000004 en Copyright © Pietro Gareri et al.