2026-05-03T02:38:01Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/aadc.000031 2025-10-02 PTZ.AADC:VOL9

Why Does Neuroplasticity Fail to Rescue the Alzheimer’s Brain? Biological Brakes and Philosophical Reflections Beyza AksuBekir Faruk Erden<p>Alzheimer’s disease represents a paradox in which the brain’s intrinsic capacity for neuroplasticity fails to prevent progressive decline. Unlike stroke, where intact circuits can reorganize and restore function, AD is marked by diffuse degeneration and active molecular brakes that suppress recovery. This article reviews the dual barriers of myelin-associated inhibitors and chronic neuroinflammation, and further considers the philosophical implications of conditional plasticity. Therapeutic strategies must therefore aim both to release inhibitory signaling pathways and to support the structural substrate of cognition.</p> Annals of Alzheimer's and Dementia Care - Peertechz Publications 2025-10-02 Letter to Editor https://doi.org/10.17352/aadc.000031 en Copyright © Beyza Aksu et al.