2026-04-05T12:51:08Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/abse.000009 2018-12-21 PTZ.ABSE:VOL4

Microwave Irradiated and Conventional Synthesis, Antibacterial Activity Evaluation Studies of Tryptamine-Azole-Fluoroquinolone Conjugates Yıldız Uygun Cebeci1 Serap Basoglu Özdemir1 Ahmet Demirbas1 Neslihan DemirbasSengül Alpay Karaoglu<p>Tryptamine was converted to the corresponding 1,2,4-triazole, 1,3,4-oxadiazole, 5-oxo-1,3-thia(oxa)zolidine and 5-(4-chlorophenyl)-1,3-thia(oxa)zole derivatives via several steps. 1,3,4-oxadiazole and 1,2,4-triazoles were then converted to the corresponding Mannich bases containing fluroquinolone core using a one-pot three-components procedure. Conventional and microwave-assisted methods were applied for all syntheses. All the newly synthesized compounds were screened for their antibacterial and most of them were found to have good–moderate antibacterial activity.</p> Archive of Biomedical Science and Engineering - Peertechz Publications 2018-12-21 Research Article https://doi.org/10.17352/abse.000009 en Copyright © Yıldız Uygun Cebeci1 et al.