2026-04-09T13:51:39Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/abse.000019 2020-09-14 PTZ.ABSE:VOL6

Bacteriocin: A potent therapeutic weapon used as an alternative to antibiotics Vidya Chauhan<p>Bacteriocin has proved its potential as an alternative therapeutic molecule. The discovery of bacteriocin has been a miracle to combat Antibiotic Resistance including both multidrug-resistant and chronic bacterial infections. They are ribosomally synthesised Anti-Microbial Protein (AMP), produced by bacteria [1,2]. Many species of bacteria develop this antimicrobial defence for self-preservation and competitive advantage. In comparison to antibiotics bacteriocin are sensitive to proteases and being undisruptive for human consumption [3]. Bacteriocins are small cationic (30–60 amino acids), membrane-permeabilizing peptides produced by Gram-positive (small- 2-6kDa)/negative (large- &gt;10kDa&lt;20kDa) bacterial species. Bacteriocins of Gram-negative bacteria are usually released through cell lysis often dependent on SOS regulation. Gram-positive bacteria follow self-regulated and dedicated transport mechanisms to release bacteriocin. These bacteriocins have a varied spectrum of activity, mode of action and biochemical properties [4,5].&nbsp;</p><p><br></p> Archive of Biomedical Science and Engineering - Peertechz Publications 2020-09-14 Mini Review https://doi.org/10.17352/abse.000019 en Copyright © Vidya Chauhan et al.