2026-04-09T07:32:11Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/ac.000008 2017-07-03 PTZ.AC:VOL2

Fever Induced Brugada Syndrome Aditya A Munshi<p>Brugada syndrome is a heterogeneous genetic channelopathy that predisposes to ventricular arrhythmias and sudden cardiac death (SCD). The electrocardiogram (ECG) findings only suggest a diagnosis of Brugada syndrome but are not confirmatory. The ECG pattern is known to vary with time in some patients and many have a normal baseline ECG [1,2]. There are two distinctly described ECG patterns, type I Brugada is characterized by ST elevation (≥2mm) with a “coved” pattern or a T-wave which is inverted with an upward convexity, in other cases the elevated ST segment descends and rises again forming a “saddleback” type pattern, this is called the type II Brugada. The electrophysiological and clinical manifestations of this syndrome have been found to be secondary to various factors [3-10]. Of these, mutations in cardiac sodium channel SCN genes (SCN5A and SCN10A) are the most well-known [11]. Since all affected families do not have these mutations, it is believed that other mutations in sodium channel genes or mutations in non-sodium channel genes may also cause Brugada syndrome [12-15].</p> Annals of Circulation - Peertechz Publications 2017-07-03 Letter to Editor https://doi.org/10.17352/ac.000008 en Copyright © Aditya A Munshi et al.