2026-05-20T09:04:08Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/ac.000026 2025-11-12 PTZ.AC:VOL10

Acquired Hemophilia-A Mimicking Trauma-induced Coagulopathy in a Young Polytrauma Patient Andrea Capponi<p>Trauma-induced coagulopathy (TIC) is a common early complication in major trauma, typically presented with prolonged PT and aPTT. However, isolated or disproportionate aPTT prolongation warrants consideration of alternative diagnoses, such as acquired hemophilia A, a rare autoimmune disorder marked by factor VIII inhibitors and severe bleeding. This case describes a young, previously healthy trauma patient whose presentation mimicked TIC but was ultimately diagnosed with acquired hemophilia A, requiring immunosuppressive therapy and bypassing agents. The case underscores the importance of maintaining a broad differential diagnosis for coagulopathy in trauma settings to ensure timely recognition and appropriate management of rare but life-threatening conditions.</p> Annals of Circulation - Peertechz Publications 2025-11-12 Case Report https://doi.org/10.17352/ac.000026 en Copyright © Andrea Capponi et al.