2026-06-03T19:47:16Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/ahr.000028 2021-01-28 PTZ.AHR:VOL7

Lipid nanoparticulate drug delivery system for the treatment of hepatic fibrosis Swarupananda Mukherjee Ayon DuttaDipanjana Ash<p>Background: Irreversible hepatic fibrosis, an excessive production and accumulation of extra cellular matrix by hepatic stellate cells in the liver, becomes a remarkable economic burden in global health care system.Low therapeutic efficacy and undesirable systemic effect of conventional therapies limit their clinical applications to targethepatic stellate cells.</p><p>Method: Surface engineered lipid nano-particle becomes a potential candidate to deliver anti-fibrotic nutrients or Small interfering RNA (siRNA) of fibrogenic genes for treating hepatic disorders.&nbsp;</p><p>Conclusion: This mini review focuses on different strategies of surface engineered organic lipid nanoparticles for the treatment of hepatic fibrosis by targeting specific and un-specific Hepatic Stellate Cells (HSCs).</p> Archives of Hepatitis Research - Peertechz Publications 2021-01-28 Mini Review https://doi.org/10.17352/ahr.000028 en Copyright © Swarupananda Mukherjee et al.