2026-04-29T14:33:55Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/amm.000024 2021-01-06 PTZ.AMM:VOL5

Nutritional intervention for cancer sarcopenia Takuya Mori Akira Kido Isao Kawahara Shota Nuaga Yoshihiro Miyagawa Kei Goto Shiori Mori Shingo Kishi Kiyomu Fujii Rina Fujiwara-TaniHiroki Kuniyasu<p>Most patients with advanced cancer develop skeletal muscle atrophy called sarcopenia, which reduces treatment tolerance and social activity and worsens the prognosis. Glucose suppresses skeletal muscle atrophy in cancer-bearing mice, while promoting cancer growth. In contrast, medium-chain fatty acids reduce skeletal muscle atrophy and suppress cancer growth. Simultaneous administration of glucose and medium-chain fatty acids suppresses skeletal muscle atrophy and eliminates the tumor growth seen in glucose. Based on these findings, dietary intervention using a combination of glucose and medium-chain fatty acids is expected to be effective in suppressing sarcopenia in cancer patients.</p> Annals of Musculoskeletal Medicine - Peertechz Publications 2021-01-06 Research Article https://doi.org/10.17352/amm.000024 en Copyright © Takuya Mori et al.