2026-05-25T13:00:46Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/aprc.000027 2017-07-13 PTZ.APRC:VOL3

Review of the literature about Thymic Carcinomas Mona MlikaFaouzi Mezni<p><strong>Background: </strong>Thymic carcinomas (TC) are rare tumors with challenging diagnosis and management. We aimed to describe the clinical and microscopic characteristics of TC through a literature review.</p><p><strong>Results:</strong> 82 articles and abstracts were retained about 2913 TC. Our study contained 1760 men and 1153 women with a mean age of 55.32 years. The delay of diagnosis was specified in 10 cases and varied between 8 months and 2 years. Symptoms consisted mainly in chest pain and dyspnea. The Computed Tomography-scan&nbsp; (CT-scan) findings&nbsp; were&nbsp; specified&nbsp; in&nbsp; 63&nbsp; cases.&nbsp; Microscopic findings&nbsp; were&nbsp; noticed&nbsp; in 1766&nbsp; cases.&nbsp; They&nbsp; consisted&nbsp; mainly&nbsp; in&nbsp; squamous&nbsp; cell&nbsp; carcinoma&nbsp; in&nbsp; 1297&nbsp; cases&nbsp; and&nbsp; undifferentiated carcinoma in 239 cases. The patients presented stage 1 tumors in 165 cases, stage II in 362 cases, stage III in 1011 cases and stage IV in 1166 cases. The treatment modalities were noticed in 2803 cases. There was no consensus of the regimen of chemotherapy or the place of the radiation therapy but all studies highlighted the key role of the complete surgical resection when possible.</p><p><strong>Conclusion:</strong> Our&nbsp; results&nbsp; highlight&nbsp; the&nbsp; lack&nbsp; of&nbsp; consensual&nbsp; management&nbsp; of&nbsp; TC.&nbsp; The&nbsp; chemotherapy regimen,&nbsp; the&nbsp; second-line&nbsp; chemotherapy&nbsp; and&nbsp; the&nbsp; indications&nbsp; of&nbsp; radiation&nbsp; therapy&nbsp; seem&nbsp; non-consensual and&nbsp; need&nbsp; further&nbsp; studies.&nbsp; Many&nbsp; interrogations&nbsp; remain&nbsp; concerning&nbsp; the&nbsp; management&nbsp; of&nbsp; these&nbsp; tumors according&nbsp; to&nbsp; their&nbsp; histologic&nbsp; grade.&nbsp; The&nbsp; real&nbsp; place&nbsp; of&nbsp; targeted&nbsp; therapy&nbsp; remains&nbsp; to&nbsp; assess&nbsp; and&nbsp; the&nbsp; rare opinions published are based on rare and non-representative cases.</p> Archives of Pulmonology and Respiratory Care - Peertechz Publications 2017-07-13 Review Article https://doi.org/10.17352/aprc.000027 en Copyright © Mona Mlika et al.