2026-05-25T15:30:55Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/asb.000023 2024-11-15 PTZ.ASB:VOL7

A Rapid Fluorescent in vitro Assay Suitable for Studying the Kinetics of O6-Alkylguanine Lesion Progression to DNA Inter-Strand Cross-Links and the Kinetics of the Primary Lesion’s Repair Philip G Penketh<p>An assay is described that permits the study of the kinetics of DNA cross-link precursor formation, the kinetics of cross-formation, and the kinetics of the repair of these DNA cross-link precursor lesions, at physiological pH values. Due to the relatively rapid nature of these processes existing assays are not suited to the study of these processes. Data obtained using this assay can be used to optimize the design of certain classes of anticancer drugs.</p> Annals of Systems Biology - Peertechz Publications 2024-11-15 Opinion https://doi.org/10.17352/asb.000023 en Copyright © Philip G Penketh et al.