2026-04-09T21:31:02Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/asmp.000006 2017-07-03 PTZ.ASMP:VOL2

Is CRISPR a fear Against Sports? Korkut Ulucan<p>One of the most worrying applications of molecular technology in sport is the gene doping, which is an outgrowth of gene therapy. In gene therapy, the missing or out- functioned gene or gene fragment is replaced with the functioning one,by the help of transfectionable devices such&nbsp; as viruses.In gene doping,the interested region is mostly the genetic material for enhancing athletic&nbsp; capacity.World Anti-doping Agency defined gene doping as the “non therapeutic use of cells,genes, genetic elements,or modulation of gene expression,having the capacity to enhance performance”. To&nbsp; date,different researchers have attempted to inject different types of genes to model organisms [1,2], but still these approaches are far from safeness in humans, even in medical area.A&nbsp; new&nbsp; gene&nbsp; editing&nbsp; strategy&nbsp; gives&nbsp; promise for genome editing.&nbsp; Many&nbsp; scientists&nbsp; have&nbsp; now&nbsp; an&nbsp; opportunity&nbsp; to&nbsp; edit&nbsp; an&nbsp; <br>organism&nbsp; genome by clustered, regularly interspaced,short palindromic repeat (CRISPR) technology.By this technology,with the help of RNA-guided nucleases, such as CRISPR Associated Protein 9 (Cas9), it is possible to modify endogenous genes by using a modified CRISPR-Cas9 system.This modified system will not only spur the development of novel molecular therapeutics for medication of diseases,but also perform targeted,highly&nbsp; efficient alterations of genome sequence and gene expression [3]. <br></p> Archives of Sports Medicine and Physiotherapy - Peertechz Publications 2017-07-03 Editorial https://doi.org/10.17352/asmp.000006 en Copyright © Korkut Ulucan et al.