2026-04-05T17:06:03Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/gjbbs.000003 2015-07-06 PTZ.GJBBS:VOL1

MicroRNAs in Oncology Yusuf Tutar<p>MicroRNAs (miRNAs) are a family of short non-coding RNA molecules which contain about 18-24 nucleotides.miRNAs play significant regulatory roles in biological processes (cell proliferation, differentiation,survival and motility). miRNAs are essential regulators of coding genes at the post-transcriptional level.The biogenesis of miRNAs is composed of complex processes, and human genome contains approximately two thousand miRNAs (http://www.mirbase.org) [1,2]. Expression patterns of miRNAs have been found to have links with pathogenesis of many diseases including neurodegenerative diseases, diabetes, cardiovascular diseases,and particularly cancer.miRNAs have been identified as a critical biomarker for treatment, diagnosis, and progression of cancer.Experimental and computational data indicates that miRNAs are up-regulated or down-regulated in cancer cells, and therefore, they<br>have oncogenic (oncomirs) or tumor-suppressive roles in apoptosis,angiogenesis, proliferation, metastasis, and differentiation in cancer cells [<br></p> Global Journal of Biotechnology and Biomaterial Science - Peertechz Publications 2015-07-06 Editorial https://doi.org/10.17352/gjbbs.000003 en Copyright © Yusuf Tutar et al.