2026-04-09T14:30:35Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/gjbbs.000005 2016-02-22 PTZ.GJBBS:VOL2

Ruta graveolens Protects Against Isoniazid/Rifampicin-Induced Nephrotoxicity through Modulation of Oxidative Stress and Inflammation Ayman M Mahmoud Omnia E Hussein Mousa O Germoush<p><strong>Background and Aim</strong> Drug-induced nephrotoxicity is a renal dyfunction that arises as a result of exposure to nephrotoxic drugs. Anti-tuberculosis therapy can cause nephrotoxicity and permanent kidney&nbsp; damage. The&nbsp; current&nbsp; study&nbsp; was&nbsp; designed&nbsp; to&nbsp; evaluate&nbsp; the&nbsp; possible&nbsp; protective&nbsp; effects&nbsp; of Ruta graveolens L. leaves extract against isoniazid/rifampicin-induced nephrotoxicity in rats.</p><p><strong>Methods</strong>:The experimental rats received isoniazid and rifampicin at dose level of 50 mg/kg, and 50 or 100 mg/kg/day Ruta graveolens leaves extract orally for 45 days.</p><p><strong>Results: </strong>Isoniazid/ rifampicin administration induced kidney injury evidenced by the histopathological alterations as well as significant (P&lt;0.001) increase in serum creatinine, urea and uric acid. soniazid/rifampicin-intoxicated rats exhibited a significant increase in serum tumor necrosis factor alpha (P&lt;0.001), and renal lipid peroxidation (P&lt;0.01) and nitric oxide (P&lt;0.001) levels. On the other hand, reduced glutathione level, and activity of superoxide dismutase and glutathione peroxidase were&nbsp; markedly&nbsp; (P&lt;0.001)&nbsp; declined&nbsp; in&nbsp; kidney&nbsp; of&nbsp; isoniazid/rifampicin-induced rats.Concomitant supplementation&nbsp; with&nbsp; either&nbsp; 50 or 100&nbsp; mg/kg&nbsp; dose&nbsp; of Ruta&nbsp; graveolens&nbsp; leaves&nbsp; extract&nbsp; prevented&nbsp; the isoniazid/rifampicin-induced biochemical and histopathological alterations. </p><p><strong>Conclusion:</strong>The present investigation confers new information on the protective mechanism of Ruta graveolens leaves extract on anti-tuberculosis therapy-induced nephrotoxicity.Ruta graveolens protects&nbsp; against isoniazid/rifampicin-induced renal injury through attattenuation of inflammation and oxidative stress, and potentiation of the antioxidant defense system.</p> Global Journal of Biotechnology and Biomaterial Science - Peertechz Publications 2016-02-22 Research Article https://doi.org/10.17352/gjbbs.000005 en Copyright © Ayman M Mahmoud et al.