2026-04-09T14:30:42Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/gjbbs.000006 2016-04-28 PTZ.GJBBS:VOL2

Nano-Technological Approaches to Improve the Efficiency of Bio-Assays Shibsekhar Roy<p>One of the biggest issues in today’s healthcare industry is to find a very fast yet effective diagnostic platform, which is suitable for our busy lifestyle&nbsp; without&nbsp; compromising&nbsp; the&nbsp; detection&nbsp; efficiency.&nbsp; The&nbsp; major requirements of an efficient diagnostic platform can be summarized as minimum sample requirement, least reagent requirement, having options of multiple tests in a single platform, high through put analysis and last but never the least a non-expensive sample run. The largest contributor&nbsp; of&nbsp; the&nbsp; bio-assay&nbsp; industry&nbsp; is&nbsp; protein&nbsp; based&nbsp; chromogenic bio-assays,&nbsp; which&nbsp; depends&nbsp; on&nbsp; strong&nbsp; antigen-antibody&nbsp; interaction and&nbsp; high&nbsp; emissive&nbsp; properties&nbsp; of&nbsp; reporter&nbsp; dye&nbsp; molecule&nbsp; attached&nbsp; to the antigen. In reality, this apparently simple looking reaction system has to face several difficulties before an appreciable signal is received by&nbsp; the&nbsp; photo-detector&nbsp; to&nbsp; give&nbsp; an&nbsp; analysable&nbsp; dataset.&nbsp; With&nbsp; the&nbsp; rapid emergence&nbsp; of&nbsp; nanotechnology&nbsp; during&nbsp; last&nbsp; few&nbsp; decades,&nbsp; some&nbsp; of&nbsp; the critical&nbsp; problems&nbsp; have&nbsp; been&nbsp; solved&nbsp; [1-5 ].&nbsp; However,&nbsp; a&nbsp; large&nbsp; number of&nbsp; unresolved&nbsp; issues&nbsp; still&nbsp; remain&nbsp; there.&nbsp; This&nbsp; editorial&nbsp; will&nbsp; briefly address some of those critical issues and how they have been tackled by&nbsp; nanotechnology.&nbsp; The&nbsp; two-most&nbsp; tunable&nbsp; variables&nbsp; of&nbsp; a&nbsp; bio-assay platform&nbsp; are&nbsp; the&nbsp; reporter&nbsp; molecules&nbsp; and&nbsp; the&nbsp; sensing&nbsp; platform&nbsp; as described by the Figure 1. We will describe both the issues separately in the next sections. </p> Global Journal of Biotechnology and Biomaterial Science - Peertechz Publications 2016-04-28 Mini Review https://doi.org/10.17352/gjbbs.000006 en Copyright © Shibsekhar Roy et al.