2026-05-18T10:57:44Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/gjfr.000013 2019-09-16 PTZ.GJFR:VOL4

Prediction of Premature Ovarian Insuffi ciency and prevalence of medical diseases El-Jabu H Elfortia I Andisha A Gerriw B Ben-Saleh H Abukail R Mlitan H El-Gomati EElmahjoob E <p><strong>Background:</strong> Premature Ovarian Failure (POF) represents 1% among women below the age of 40 and can be diagnosed by two levels of serum Follicular Stimulating Hormone (FSH) ≥40mIU/mlat 6&nbsp;weeks apart. There are many reasons for POF and commonly is idiopathic (60% to 80%). POF has a negative impact on the psychological, social and quality of life of females.</p><p><strong>Objective:</strong> This study aims to find the possibility of prediction of Premature Ovarian Insufficiency (POI) and its relation to medical disorders.</p><p><strong>Materials and methods:</strong> A retrospective study was conducted at the National Center for Diagnosis and Treatment of Infertility- Misurata, Libya. A total of 350 patients with POI were involved. The Inclusion Criteria were: age &lt;40 years, with high serum FSH level, low Anti-Mullrian Hormone (AMH) and low Antra-Follicular Count (AFC). The hormonal essay including FSH, Luteinzing Hormone (LH), Estradiol (E2), Thyroid-Stimulating Hormone (TSH), Prolactin and Fasting Blood Sugar (FBS) along with the medical history was collected.</p> <p><strong>Results:</strong> Overall collected cases had a mean age (31.19±3.86&nbsp;years) and the medical disorders represented 47% of POI causes. Hypothyroidism, Hyperprolactinemia and Diabetes Mellitus were the most common associated disorders (31%, 30%, 14% respectively). The increase in the level of FSH (14.78±12.87) was the most sensitive test to predict POI especially in hypothyroidism cases, which could help to predict ovarian failure in those groups of people.</p> <p><strong>Conclusion:</strong> There is a strong association between POI and medical conditions especially Hypothyroidism. Changes in FSH are the most sensitive test among ovarian markers to predict POF.</p> Global Journal of Fertility and Research - Peertechz Publications 2019-09-16 Research Article https://doi.org/10.17352/gjfr.000013 en Copyright © El-Jabu H et al.