2026-04-14T17:18:03Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/ijpsdr.000002 2015-05-23 PTZ.IJPSDR:VOL1

A Pharmacokinetic Analysis and Pharmacogenomic Study of 6-mercaptopurine Vicha A Katsila T Giannopoulou E Leontari H El Mubarak M Gravia A Chondrou V Symeonidis A Patrinos GP Kalofonos HPSivolapenko G<p><strong>Background:</strong> The efficacy and safety of 6-mercaptopurine (6-MP) therapy rely on the concentration of its metabolites. The aim of the current study is the pharmacokinetic analysis of 6-MP and the detection of its metabolites as well as the role of Thiopurine S-methyl transferase (TPMT), the enzyme associated with 6-MP metabolism, as a pharmacogenomics biomarker.</p><p><strong>Materials and Methods:</strong> Data were collected from 19 patients with different types of leukemia and lymphoma who received 6-MP chemotherapy. Pharmacokinetic analysis was performed using an HPLC. The VNTR promoter polymorphisms of TPMT were detected.</p><p><strong>Results and Conclusion:</strong> The pharmacokinetic analysis confirmed the heterogeneity of the 6-MP metabolism. The TPMT genotyping revealed a correlation between the TPMT*3C variant and increased levels of 6-thioguanine nucleotides (TGs). No methylation pattern was obtained.</p> International Journal of Pharmaceutical Sciences and Developmental Research - Peertechz Publications 2015-05-23 Research Article https://doi.org/10.17352/ijpsdr.000002 en Copyright © Vicha A et al.