2026-05-18T05:13:01Z
https://www.peertechzpublications.org/oai-pmh
oai:www.peertechzpublications.org:10.17352/ijrro.000026
2018-03-15
PTZ.IJRRO:VOL4
Hyperprogression after immunotherapy in HNC: literature review and our experience
Nerina Denaro<!--[if gte mso 9]><xml>
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<p class="MsoNormal">Checkpoint inhibitors demonstrate salutary anticancer effects, including long-term remissions. PD-L1 expression/amplification, high mutational burden, and mismatch repair deficiency correlate with response. Champiat et al for the first time described a small subset of patients that could actually have tumor growth accelerated when given PD1/PDL1-targeting agents [1].</p><p class="MsoNormal">Hyperprogression may be defined as accelerated progression outpaces the expected rate of growth induced by the therapies.</p><p class="MsoNormal">Champiat suggests that a subset of patients with disease progression have a course that is more deleterious than they might have had with other therapies, or even in the absence of therapy.</p>
International Journal of Radiology and Radiation Oncology - Peertechz Publications
2018-03-15
Case Report
https://doi.org/10.17352/ijrro.000026
en
Copyright © Nerina Denaro et al.