2026-05-25T06:41:49Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/jbm.000015 2019-08-20 PTZ.JBM:VOL3

The association between copy number variant of Angiotensin Converting Enzyme gene and the risk of Ascending Aortic Aneurysm in Bicuspid and Tricuspid Aortic Valve Azadeh Motavalli Naeini Maryam Sotoudeh Anvari Shayan Ziaee Ali Hosseinsabet Mohammadali BoroumandKyomars Abbasi<p><strong>Introduction</strong>: The presence of ACE Insertion/Deletion polymorphism is proposed to be associated with a higher risk for abdominal aortic aneurysm. The aim of this study was to examine a relationship between the occurrence of I/D polymorphism among patients with ascending aortic aneurysm and bicuspid or tricuspid aortic valve structure.</p><p><strong>Material and method</strong>: In this case–control study, 360 patients divided into two groups: 1) patients with ascending aortic aneurysm and bicuspid or tricuspid aortic valve (n= 175), and 2) those without ascending aortic aneurysm as control samples (n=185). The presence of copy number variant (CNV) patterns (Insert/Deletion) of ACE gene was analyzed using real-time polymerase chain reaction.</p> Journal of Biology and Medicine - Peertechz Publications 2019-08-20 Research Article https://doi.org/10.17352/jbm.000015 en Copyright © Azadeh Motavalli Naeini et al.