2026-05-09T22:29:35Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/jgro.000085 2020-06-10 PTZ.JGRO:VOL6

Novel therapy for COVID-19 does intravenous ozonated-saline affect blood and tissue oxygenation? Thorp JA Hollonbeck SA Viglione DD Green PC Hodge JR Tamburro JA Tran TNGlassman DS<p>Introduction: Adjunctive ozone therapy for COVID-19 is being used successfully in China, Spain, Italy, and South America. One proposed mechanism is by improving blood / tissue oxygenation thus averting multiorgan system failure due to hypoxia. The purpose of this study was to determine if ozonated-saline administered intravenously affects the oxygenation and duration of time spent in a hypoxia chamber.</p><br><p>Materials and methods: This was a prospective pilot study that used one volunteer who underwent seven experiments. Each included two runs in a hypoxia chamber that resulted in symptomatic oxygen desaturation. One subject was used as his own control in the hypoxia chamber before and after infusion of intravenous ozonated-saline in four paired experiments.Another 3 experiments were performed identically except ozone was not administered. The primary outcome was to test the null hypothesis that ozonated-saline infusion does not affect oxygenation.</p><br><p>Results: In four experiments, ozone was associated with a significant increase in time the subject could remain in the hypoxia chamber (P&lt; 0.05). In three control experiments without ozone, there was a significant decrease in time in the hypoxia chamber in the second run compared to the first (P &lt;0.001). Compared to the first run there was a 32.4% increase in the proportion of time in the second run (after ozone) compared to the first run (P &lt;0.0001). In contrast, in the three control experiments without ozone, there was significant decrease in proportion of time the subject could remain in the hypoxia chamber with an average decrease of -43.1% (P &lt; 0.0001). Ozone therapy was associated with a significant delay in lowest oxygen desaturation (P &lt;0.05). In contrast, in the three experimental runs without ozone there was a significant reduction in time to reach the nadir of the desaturation curve in the second run compared to that of the first (P &lt; 0.05).</p><br><p>Conclusions: Infusion of intravenous ozonated-saline significantly increases the duration of time that a subject can remain in hypoxia and delays the nadir of the oxygen de-saturation curve.</p> Journal of Gynecological Research and Obstetrics - Peertechz Publications 2020-06-10 Research Article https://doi.org/10.17352/jgro.000085 en Copyright © Thorp JA et al.