2026-04-29T17:50:36Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/oja.000004 2017-04-12 PTZ.OJA:VOL1

Is Serum Tryptase a Valuable Marker for Obesity-Bronchial Asthma Interrelationship in Children? Abdel Gawad TA Terez B Kamel Manal M Abd Al-Aziz Abou-Sekin TAMourad Alfy Ramzy<p><strong>Background: </strong>Asthma among obese represents a unique phenotype. Mast cells are more abundant inobese. Serum tryptase (ST) is a marker of mast cell numbers or activity. Since obesity and asthma have been linked in epidemiological studies, a possible higher mast cell activity in obesity could be a factor between the two conditions. This study was to investigate ST and its potential association between obesity and childhood asthma.</p><p><strong>Methods: </strong>Study recruited 60 asthmatic children, their age ranged from 5-16 years. They were divided according to BMI centile to 30 obese and 30 non-obese asthmatics. Thirty healthy non-asthmatic,&nbsp; nonatopic and non-obese children; were included as a healthy control. Serum tryptase, atopy (skin prick test reactivity) and spirometry were assessed.</p><p><strong>Results:</strong> Frequency of atopy and positive skin prick test significantly increased among obese more than non-obese asthmatics (P&lt;0.05, OR = 1.96, 95% CI = 1.27-3.24). FEV1% of predicted mean levels were lower among obese than non-obese asthmatics (p&lt;0.05). ST was significantly higher in asthmatics than in controls with a mean ±SD of 53.3±13.78 ng/ml and 10.06±4.39 ng/ml respectively. ST was higher in obese than non-obese asthmatics with a mean ±SD of 71.73±19.17 ng/ml and 34.5±8.68 ng/ml&nbsp; respectively (P&lt;0.05). There was a negative correlation between ST and FEV1 % of predicted and&nbsp; positive correlations between ST and age, BMI, and waist circumference among asthmatics. <br></p><p><strong>Conclusion: </strong>Mast cells play a role in both obesity and asthma, serum tryptase, being a marker of mast cell activation, could represent a link between them.</p> Open Journal of Asthma - Peertechz Publications 2017-04-12 Research Article https://doi.org/10.17352/oja.000004 en Copyright © Abdel Gawad TA et al.