2026-04-19T18:42:20Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/ojabc.000033 2025-03-25 PTZ.OJABC:VOL9

Highly Protein-resistant AuNPs-ampholytes Modified Boric Acid Hydrogel for Saliva Glucose Detection Qian Dou Tingjun Chen Liping Zhu Qing DaiDebo Hu<p>Saliva glucose detection using QCM technology has garnered significant attention of non-invasive blood glucose monitoring. Introducing antifouling materials is a pivotal strategy for addressing the issue of indiscriminate protein adsorption in saliva. Nonetheless, equipping surfaces with antifouling properties often comes at the cost of compromising the sensitivity&nbsp; of QCM tests. To tackle this challenge, we engineered an innovative antifouling hydrogel that integrates gold nanoparticles functionalized with L-cysteine (Au-Cys). When immobilized on quartz chips, this hydrogel not only enhanced glucose sensitivity but also significantly reduced nonspecific protein adsorption . The sensitivity of hydrogels without Au-Cys increased from 0.34 Hz/(mg/L) to 0.45 Hz/(mg/L) of hydrogels containing Au-Cys.&nbsp; Additionally, protein adhesion of bovine serum albumin, lysozyme, and mucin was markedly decreased by approximately 25, 10, and 50 times, respectively.</p> Open Journal of Analytical and Bioanalytical Chemistry - Peertechz Publications 2025-03-25 Review Article https://doi.org/10.17352/ojabc.000033 en Copyright © Qian Dou et al.