2026-04-23T14:05:37Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/ojbs.000003 2016-05-04 PTZ.OJBS:VOL1

Correlation Analysis between mtDNA G10398A Polymorphism and Susceptibility of Patients with Type 2 Diabetes Mellitus in Northwest China Ting Ji Chen Tian Xin-Zhong Ji Li Huang Yun-Cong Wang Han Liu Xiao-Dong Xie<p><strong>Introduction:</strong> The present work aimed to investigate the association between G10398A polymorphism in mtDNA with type 2 diabetes mellitus (T2DM) susceptibility among Chinese northwestern population.</p><p><strong>Methods:</strong> Polymerase chain reaction followed by the restriction digestion of the amplicon to clarify the restriction fragment length polymorphism (PCR-RFLP) was used to score the G10398A variation of mtDNA NADH dehydrogenase3 (ND3) locus in a case-control study (n=422), including 209 patients with T2DM and 213 healthy controls.</p><p><strong>Results:</strong> The genotypes of G10398A were AA, AG, GG and the frequencies of genotypes and allele distributions were not significantly different in T2DM patients compared to healthy controls (P&gt;0.05, χ2 test). There were no significant differences between genotypes and clinic indicators (P&gt;0.05, single factor analysis of variance).</p><p><strong>Conclusions:</strong> The findings indicated that G10398A SNPs in ND3 locus of mtDNA were not in association with T2DM susceptibility in this population.</p> Open Journal of Biological Sciences - Peertechz Publications 2016-05-04 Research Article https://doi.org/10.17352/ojbs.000003 en Copyright © Ting Ji et al.