2026-06-09T19:53:49Z https://www.peertechzpublications.org/oai-pmh

oai:www.peertechzpublications.org:10.17352/sscrt.000001 2015-03-30 PTZ.SSCRT:VOL1

Expectations of Epigenetic Research Studies Focusing on Mesenchymal Stem Cells Shigetaka Asano<p>Epigenetic alternations are not associated with any changing the base sequence of DNA, but are closely related to phenome together&nbsp; with genome [1]. Most of them are determined differvvently under various&nbsp; external and internal influences and, even if abnormal, memorized over individual life. In the ontogeny that starts from a totipotent stem cell such as a fertilized egg, the epigenetic alternations occur in good order along with cell differentiation process toward peculiar epigenetic patterns of individual cell series. In&nbsp; contrast, a reverse artificial phenomenon induced by transduction of 4 genes, Oct3/4, Sox2, Klf4 and c-Myc (induced progenitor and stem cells: iPS cells) is known to accompany with significant abnormalities of DNA methylations, one of the epigenetic regulation mechanisms, fearing possible abnormal cell&nbsp; development. These cells should be used for elucidation of unknown reprogramming mechanisms rather&nbsp; than rough- and ready-clinical applications.</p> Studies on Stem Cells Research and Therapy - Peertechz Publications 2015-03-30 Editorial https://doi.org/10.17352/sscrt.000001 en Copyright © Shigetaka Asano et al.