https://www.cancerresgroup.us/journals/annals-of-bone-marrow-research A Peertechz Open Access Journal en-us 26 Nov, 2024 https://www.cancerresgroup.us/articles/ABMR-9-111.php Introduction: Integration of digital technologies is imperative across sectors like healthcare and education. This shift presents opportunities to enhance medical services and transform learning for future healthcare professionals. This study evaluates Libyan medical institutions’ readiness for the digital age, emphasizing its importance for quality assurance and accreditation. Materials and methods: A quantitative survey was sent to all the medical faculties deans in Libya (Appendix 1 ). Results: Surveys gathered responses from 47% of deans representing 17 medical faculties in Libya. Insights emerged on digital transformation dimensions. Positive aspects included an administrative commitment to digital transformation, the pedagogical shift towards student-centered learning, and teacher training support. Challenges included digital infrastructure, resource availability, budgetary constraints, and limited student access to digital tools, emphasizing the need for equitable access. Data security and privacy compliance were strong, with room for data quality improvements. Discussion and conclusion: This study emphasizes leadership awareness among responders regarding digital readiness. Recommendations encompass investments in digital infrastructure, integration of high-quality digital learning materials, and ensuring equitable student access, community engagement, and staying current with emerging technologies are essential. It is mandatory to empower Libyan medical establishments to navigate digital transformation and to create a robust digital ecosystem to enhance patient care. 12 Sep, 2023 https://www.cancerresgroup.us/articles/ABMR-8-110.php Chemotherapy-Induced Neutropenia (CIN) is a potentially fatal side effect of cancer treatment, affecting > 50% of cancer patients treated with chemotherapy. Clinical use of recombinant human granulocyte colony-stimulating factor (rhG-CSF) has allowed for primary and secondary prophylaxis of CIN and its sequela (i.e., febrile neutropenia, fatal infection) during myelosuppressive chemotherapy. Here, we review the translation and properties of first, second, and third-generation rhG-CSF molecules, including filgrastim (Neupogen, FDA approved in 1991) and biosimilars, pegfilgrastim (Neulasta, FDA approved in 2002) and biosimilars, and F-627 (Ryzneuta, NMPA approved in 2023), a novel long-acting rhG-CSF agent developed this past decade. Even with the development of increasingly personalized and targeted cancer therapy, chemotherapy, and stem cell transplantation remains a backbone for the majority of patients with advanced cancers, especially in the hematopoietic system. As such, more than 20 million cancer patients have been treated with rhG-CSF drugs since the first approval of filgrastim. In the next decade, we envision third-generation rhG-CSF products such as Ryzneuta lowering costs to patients and healthcare providers, expanding access to this essential medication for cancer patients worldwide, particularly for patients who require more aggressive chemotherapy treatment. 23 Jul, 2022 https://www.cancerresgroup.us/articles/ABMR-7-109.php One of the most important tasks of biotechnology and regenerative medicine is to achieve long-term expansion of hematopoietic stem cells. One of the promising approaches to optimizing the cultures of hematopoietic cells is the creation of a microenvironment in the form of feeder stromal layers, which allows for the reproduction of the combination of soluble cytokines and growth factors necessary for hematopoiesis and promotes an increase in their proliferation [1,2]. 13 May, 2021 https://www.cancerresgroup.us/articles/ABMR-6-108.php Acute Panmyelosis with Myelofibrosis (APMF) is an extremely rare disease. Lack of familiarity with this rare subtype of acute leukemia hinders the diagnosis [1]. It is characterized by an acute, rapidly progressive, fatal clinical course, peripheral blood cytopenias with minimum 20% blast and no detectable splenomegaly. APMF corresponds to less than 1% of the cases of Acute Myeloid Leukemia (AML) [2]. Histologically, APMF is characterized by a heavily fibrotic marrow, an increased number of immature hematopoietic elements (panmyelosis), and dysplastic population of megakaryocytes. The condition should be differentiated from other hematological neoplasms that present with fibrosis such as acute megakaryoblastic leukemia and myelodysplsia (MDS) with myelofibrosis. Dacrocytes are not present. 27 Jan, 2021 https://www.cancerresgroup.us/articles/ABMR-6-107.php Objectives: To assess the usefulness of proton MR-spectroscopy (1H-MRS) and diffusion-weighted MRI (DW-MRI) sequences in the follow-up of CLL-patients with chemotherapy treatment. The monitoring of CLL-patients susceptible to chemotherapy treatment is complicated due to the difficulty in assessing the response to treatment. Chemotherapy leads to changes in bone marrow composition and these changes can be evaluated by functional MR-sequences. Methods: 23 patients diagnosed with CLL by our hospital’s Hematology Service underwent a lumbar MR prior and post-chemotherapy applying 1H-MRS and DW-MRI. The concentrations of water and lipids were quantified applying the quantification program LCModel. The Apparent Diffusion Coefficient (ADC) values were calculated with the Functool program (GE). The Wilcoxon sign test was used to compare pre and post treatment results, considering statistically significant P values lower than 0.05. Results: Responder patients decreased the ratio H2O/lipids concentration measured with 1H-MRS and increased the ADC value on DW-MRI in post-treatment studies (P<0.05). Patients without response increased the ratio and decreased the ADC values or did not modify the data. Conclusion: 1H-MRS and DW-MRI of spinal bone marrow are non-invasive and repeatable techniques that might help in follow-up monitoring of patients with CLL. 04 Jun, 2020 https://www.cancerresgroup.us/articles/ABMR-5-106.php Qualified researchers from Africa, who worked in team abroad are competent. But, they cannot reproduce and develop works started abroad after returning back to home countries. In this article we will list briefly the different underlying causes, challenges, consequences and future aspiration. 15 May, 2020 https://www.cancerresgroup.us/articles/ABMR-5-105.php Introduction: Cases have been referred to our tertiary referral sarcoma service where marrow abnormalities have been identified in the proximal radius. We believe this to be a normal variant, likely representing residual red marrow. The purpose of this study is to describe the features and determine the prevalence of such a finding on elbow magnetic resonance imaging (MRI) in an unselected group of patients imaged at our institution.  08 Mar, 2017 https://www.cancerresgroup.us/articles/ABMR-2-104.php Introduction: Fanconi’s anemia (FA) is a rare genetic disorder. Patients with this disorder have progressive bone marrow failure, congenital abnormalities and are vulnerable to malignancy. 14 Feb, 2017 https://www.cancerresgroup.us/articles/ABMR-2-103.php Pepper (chili or hot pepper) is one important plant for homology of food and medicine. At present, 1/4 people world worldwide are often taking peppers, also1/4 people world worldwide have allergic constitution. 20 Dec, 2016 https://www.cancerresgroup.us/articles/ABMR-1-102.php Hematopoietic stem cell transplantation (HSCT) is an important life-saving procedure which is applied in cases of genetic defects or malignant tumors. 14 Dec, 2016 https://www.cancerresgroup.us/articles/ABMR-1-101.php We herewith introduce a 9-year-old boy presenting with leukocytosis, anemia and high lymphoblast count who had a pale complexion as well as weight loss. His cytogenetic analysis revealed aberrant chromosomal rearrangements in different clonal populations harboring 46XY karyotype with t (12; 21) (p12; q22), which was confirmed by DNA sequencing.