https://www.clinsurggroup.us/journals/archives-of-hematology-case-reports-and-reviews A Peertechz Open Access Journal en-us 14 Aug, 2025 https://www.clinsurggroup.us/articles/AHCRR-10-151.php Hemophagocytic lymphohistiocytosis (HLH) is a hyper-inflammatory syndrome driven by uncontrolled immune activation. Although Epstein–Barr virus is the prototypical infectious trigger, disseminated tuberculosis (TB) is an increasingly recognised cause, especially in endemic regions. We describe a 49-year-old woman who presented with miliary TB complicated by secondary HLH and rapidly progressive multiorgan dysfunction. Despite prompt anti-tubercular therapy (ATT) and HLH-directed immunosuppression, she died within 48 hours of intensive-care admission. The case underlines the need for early marrow evaluation and simultaneous initiation of ATT and HLH-specific therapy when TB-HLH is suspected. 19 Jul, 2025 https://www.clinsurggroup.us/articles/AHCRR-10-150.php Natural Killer (NK)/T-cell lymphoma is a rare but aggressive subtype of non-Hodgkin lymphoma, frequently associated with Epstein-Barr virus (EBV) and often complicated by rapid clinical deterioration. We present a diagnostically challenging case of a 36-year-old male with fulminant NK/T-cell lymphoma complicated by CMV and EBV co-infection, hepatic dysfunction, and suspected HLH. Despite multidisciplinary management, the patient succumbed due to rapid disease progression before full diagnostic confirmation and initiation of definitive therapy. 08 Jul, 2025 https://www.clinsurggroup.us/articles/AHCRR-10-149.php Introduction: The impact of COVID-19 extends beyond the respiratory system, encompassing complex interactions with hematologic parameters. This study investigates how SARS-CoV-2 infection contributes to anemia through alterations in Red Blood Cell (RBC) deformability, enzyme activity, and membrane protein composition, while also evaluating the clinical implications. Methods: We conducted a prospective observational study involving 74 individuals, including COVID-19-positive patients (with and without anemia), patients with other viral infections, and healthy controls. RBC-related parameters-including hemoglobin levels, enzyme activities, and Osmotic Gradient Ektacytometry (OGE) profiles-were measured. Proteomic analysis of RBC membranes was performed using advanced omics techniques. In addition, we reviewed the existing literature by searching PubMed, Scopus, and Web of Science for studies related to COVID-19 and anemia up to December 2023, using predefined inclusion criteria to contextualize our findings. Results: Anemia was significantly associated with more severe COVID-19 outcomes, including elevated D-dimer, procalcitonin, creatinine, and blood urea nitrogen levels. Proteomic analysis revealed alterations in membrane proteins linked to RBC stability and oxygen delivery. Notably, patients with COVID-19 and anemia exhibited distinct proteomic and deformability profiles compared to non-anemic individuals and those with other viral infections. Conclusion: This study highlights the multifactorial nature of anemia in COVID-19, emphasizing its contribution to hypoxia and disease progression. The integration of clinical, rheological, and proteomic data underscores the need for early screening and personalized management of anemia in COVID-19 patients, with potential implications for improving outcomes and informing future therapeutic strategies. 04 Feb, 2025 https://www.clinsurggroup.us/articles/AHCRR-10-148.php Hemochromatosis is an iron storage disorder characterized by excessive iron absorption and deposition, leading to tissue damage and organ failure. Here we report a case of a 35-year-old female with a 6-year history of diabetes mellitus and secondary amenorrhea, along with chronic liver dysfunction and severe anemia requiring frequent blood transfusions. Clinical evaluation revealed severe pallor, hepatosplenomegaly, and hypogonadism. Laboratory findings indicated severe anemia (hemoglobin 4.8 g/dL), elevated serum ferritin (>1000 ng/ml), and high transferrin saturation (82.02%). Hormonal assays confirmed secondary hypogonadism with low FSH and LH levels. Imaging and liver biopsy demonstrated iron overload, and genetic testing identified SLC40A1 mutation, confirming hereditary hemochromatosis type 4, alongside beta-thalassemia minor. The patient was managed with deferasirox for iron chelation, insulin therapy for diabetes, and hormone replacement for hypogonadism. This case highlights the importance of considering hemochromatosis in patients with diabetes, liver dysfunction, and hypogonadism, especially in the context of anemia and frequent transfusions. Early diagnosis and treatment are crucial to prevent complications and improve outcomes. Genetic testing and liver biopsy play key roles in confirming the diagnosis, particularly in non-HFE hemochromatosis. This report underscores the need for a high index of suspicion in similar clinical presentations to ensure timely intervention. 24 Dec, 2024 https://www.clinsurggroup.us/articles/AHCRR-9-147.php This study investigates the correlation between blood oxygen levels and selfie-loving. 200 graduate students participated, and their blood oxygen levels were assessed. Participants were also queried about their selfie-taking habits. The study, conducted at a University, revealed a significant correlation between selfie adoration and blood oxygen level. Excessive selfie-taking may have physiological implications, particularly on blood oxygen levels. This finding contributes to research on the psychological and physiological effects of social media behavior. The results suggest that selfie adoration can have unexpected physical consequences, highlighting the need for further investigation into the impact of social media on physical health. 22 Oct, 2024 https://www.clinsurggroup.us/articles/AHCRR-9-146.php Background: Sickle cell anemia (SCA) is a genetic disorder characterized by abnormal hemoglobin variants, including hemoglobin F (Hb F) and hemoglobin A2 (Hb A2). Evaluating the levels of these hemoglobin variants in steady-state sickle cell patients can provide insights into disease prognosis and management. This study aimed to assess Hb F and Hb A2 levels among sickle cell patients in steady state at a selected hospital in Ogun State, Nigeria. Objective: To evaluate the levels of hemoglobin F (Hb F) and hemoglobin A2 (Hb A2) in sickle cell anemia patients and determine their associations with demographic factors such as age and gender. Materials and methods: A descriptive cross-sectional study was conducted at the Sickle Cell Center, Abeokuta, Ogun State, Nigeria, from September to October 2020. A total of 60 sickle cell patients in steady state were recruited using convenient sampling. Blood samples were collected, and Hb F and Hb A2 levels were measured using high-performance liquid chromatography (HPLC). Data were analyzed using SPSS version 26.0 with independent t-test and bivariate correlation. Results: The mean levels of Hb F and Hb A2 varied across age groups and genders. Hb F levels were highest in patients over 35 years (10.4 ± 12.16%) and lowest in those aged 26-30 years (3.7 ± 1.3%). The majority of participants had Hb F levels between 2-10%, with a significant association between Hb F levels and age (p = 0.038). Hb A2 levels were consistently above 3.1% in 92.6% of the study population, with no significant association with age or gender. Conclusion: There is a significant association between age and Hb F levels among steady-state sickle cell patients, while Hb A2 levels showed no significant demographic correlations. The findings suggest that Hb F may serve as a potential marker for clinical evaluation in SCA patients. 13 Sep, 2024 https://www.clinsurggroup.us/articles/AHCRR-9-145.php Postpartum Hemorrhage (PPH) is a significant cause of maternal morbidity and mortality, often exacerbated by inadequate adherence to established guidelines. This article examines the critical role of uterine atony and explores the impact of factors such as inaccurate blood loss estimation and hematological complications. It critiques the existing clinical guidelines for insufficiently addressing the role of hematologists and proposes the integration of early assessment techniques, including viscoelastic hemostatic assays and targeted fibrinogen replacement, to more effectively manage coagulopathy. The article also highlights recent advancements, such as the Alma device, and advocates for a multidisciplinary approach that includes both obstetricians and hematologists to enhance PPH management and improve patient outcomes. 19 Jul, 2024 https://www.clinsurggroup.us/articles/AHCRR-9-144.php After a critical revision of the main results obtained on the hematic material of the Holy Shroud in Turin, this paper presents various news of both a macroscopic and microscopic nature. At a macroscopic level, news regarding the directions and position of blood and the probable presence of pulmonary fluid are discussed. Also, the bloodstains on the left arm are examined to try to distinguish different kinds of hematic fluid. At a microscopic level, three different types of blood are evidenced. Hypotheses have been formulated to distinguish pre-mortem and post-mortem blood and to distinguish erythrocytes on the basis of their different sizes. The presence of fibrin, earthy material, creatinine typical of a tortured person, and the stacking of erythrocytes is also discussed along with their Beta-activity and fluorescence. Finally, the physical conditions relating to Jesus are discussed from a medical point of view which could explain all the news of the hematic material taken from the HST and are consistent with the tortures of Jesus Christ described in the Holy Bible. 14 Sep, 2023 https://www.clinsurggroup.us/articles/AHCRR-8-143.php The study of human illnesses brought on by microbes falls under the wide category of infectious diseases. Among all other challenges, infectious diseases have a profound influence on human existence. From local epidemics to global pandemics, infectious diseases have had a huge impact on civilization growth, country destiny, and human history. Only in the late 1800s did scientists discover that infections are caused by microorganisms, leading to the development of the microbe-specific medical diagnostic technique. If identified and treated properly, many infections have mild consequences. Others, however, including pneumonia and meningitis, etc. can be fatal if neglected. With its capacity to pinpoint the precise source of infection and combat varied and widespread outbreaks, diagnostic procedures play a special role in the management of infectious diseases. Diagnosis-aid therapies work better and help the infected patient avoid long-term consequences. The most appropriate course of medication can also be decided through diagnostic testing. Patients who go undiagnosed may unintentionally spread the illness to others. A prompt diagnosis can thus contribute to the control or prevention of outbreaks. In summary, the novelty and contributions of the study lie in its recognition of the pivotal role played by diagnostic procedures in understanding, managing, and controlling infectious diseases. It also acknowledges the historical discovery of microorganisms as the root cause of infections and the development of specific diagnostic techniques, both of which have had a profound impact on the field of medicine and public health. 12 Aug, 2023 https://www.clinsurggroup.us/articles/AHCRR-8-142.php Hemorrhage from trauma, surgery, obstetric emergencies, and gastrointestinal bleeds remain a cause of potentially preventable deaths for patients. However, transfusions of large amounts of blood products may lead to complications. The development of Massive Transfusion Protocols (MTP), a proactive treatment protocol to manage profound blood loss, has shown improved outcomes for patients requiring immediate and multiple blood transfusions. These guidelines help to recognize hemorrhagic patients in need of an MTP as well as how to best manage this complex protocol. 01 Jun, 2023 https://www.clinsurggroup.us/articles/AHCRR-8-141.php Multiple Myeloma (MM) and Myelodysplastic Syndrome (MDS) are two hematological malignancies with different clinico-biological features to their specific pathogenesis and evolution. The simultaneous occurrence of these two blood diseases within the bone marrow, unrelated to prior chemotherapy, is a rare event: we report subsequently the case of a concomitant presentation of MM and MDS. This case will eventually raise several questions on the pathophysiological, and therapeutic level and on their course, in particular infections, thrombosis, extramedullary localizations, and circulating plasma cells. 30 Aug, 2022 https://www.clinsurggroup.us/articles/AHCRR-7-140.php Primary Cutaneous Anaplastic Large Cell Lymphoma (PC-ALCL) is a CD30+ lymphoproliferative disease of the skin characterized by single or focal nodules or plaques that ulcerate over time. Diagnosis of PC-ALCL relies heavily on clinicopathological correlations because of the potential morphological, clinical, and molecular overlap with other cutaneous CD30+ LPDs. Histopathologic features include diffuse nonepidermotropic infiltrates with an adherent layer of large undifferentiated CD30+ tumor cells. The Exact incidence of PC-ALCL is not known partially because of the difficulty differentiating from the variety of CD30+ Lymphoproliferative disorders. Only a few cases are reported even from developed countries & reports from developing countries are lacking. We present a possible case of primary cutaneous Anaplastic Large cell Lymphoma in a 20 years old Female patient who presented with a 2 months history of lateral neck swelling. 23 Aug, 2022 https://www.clinsurggroup.us/articles/AHCRR-7-139.php A 28-year-old man with an anterior mediastinal mass underwent total thymectomy. The surgical specimen showed multilocular cysts and nodules. On microscopic examination, the cysts were lined by squamoid epithelium, consistent with thymic cysts and tumors showing two different histologic features were identified. One tumor component was composed of sheets of monotonous, oval-to-round nuclei with pale cytoplasm and indistinct cell borders. The other tumor component comprised sheets of grooved cells admixed with eosinophils. Immunohistochemical analysis revealed different staining patterns in each component: the former was positive for D2-40, c-kit and OCT3/4; and the latter was positive for S100 protein and CD1a. Based on these histopathological and immunohistochemical findings, we diagnosed the tumor as a synchronous seminoma and Langerhans cell histiocytosis along with a thymic cyst. To the best of our knowledge, this is the first case of the coexistence of these lesions in the thymus. Coronavirus Disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) that is associated with several inflammatory and vascular endothelial complications. Ocular vascular occlusive events were reported in COVID-19 patients including both Central Retinal Vein Occlusion (CRVO) and Central Retinal Artery Occlusion (CRAO). We report a case of a 34-years-old patient with right CRVO after 14 days of COVID-19 infection presenting with decreased vision. In addition, we provide a summary of both CRVO and CRAO reported in the literature. 05 May, 2022 https://www.clinsurggroup.us/articles/AHCRR-7-138.php Hereditary elliptocytosis is a group of red blood cell membrane disorders that are characterized by elliptical-shaped erythrocytes and shortened red blood cell survival [1]. It is due to protein abnormalities involving the horizontal skeletal network of the red cell membrane, including the spectrin dimer-dimer interaction or the spectrin-actin-protein 4.1 junction complex [2]. 03 Mar, 2022 https://www.clinsurggroup.us/articles/AHCRR-7-137.php Coronavirus Disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) that is associated with several inflammatory and vascular endothelial complications. Ocular vascular occlusive events were reported in COVID-19 patients including both Central Retinal Vein Occlusion (CRVO) and Central Retinal Artery Occlusion (CRAO). We report a case of a 34-years-old patient with right CRVO after 14 days of COVID-19 infection presenting with decreased vision. In addition, we provide a summary of both CRVO and CRAO reported in the literature. 16 Feb, 2022 https://www.clinsurggroup.us/articles/AHCRR-7-136.php Hemophagocytic lymphohistiocytosis (HLH) in coronavirus disease 2019 (COVID-19) is a recognized complication of severe illness. However, this phenomenon has been reported most often in the setting of acute infection. Here we present a case of a patient with a history of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection that subsequently developed HLH weeks after treatment of COVID-19 and discharges from the hospital. Upon re-admission, work-up demonstrated the patient was experiencing Epstein-Barr virus (EBV) reactivation. As EBV infection is a known etiological trigger of HLH, this case provides an alternative mechanism for HLH seen in patients with a history of COVID-19 infection who present after the resolution of acute symptomatology. 20 Jan, 2022 https://www.clinsurggroup.us/articles/AHCRR-7-135.php Histiocytoses are clonal disorders diseases derived from the monocyte-macrophage lineage. The Erdheim–Chester Disease (ECD) and Langerhans Cell Histiocytosis (LCH) may occur in association with overlapping clinical, histopathological and molecular features, harboring somatic MAP2K1 mutations in more than 50% of patients. BRAF and MEK inhibitors have shown to be efficacious in ECD and LCH, including responses in patients with CNS involvement. This case report describes a 59-year-old woman who presented with vemurafenib-refractory ECD/LCH overlap syndrome treated with vemurafenib/cobimetinib dual therapy, with rapidly progressing neurological involvement after its initiation. Although targeted therapy plays a crucial role in the treatment of histiocytosis, only anecdotal clinical cases treated with dual therapy have been reported in ECD or LCH and collaborative trials are needed to improve outcomes. 12 Aug, 2021 https://www.clinsurggroup.us/articles/AHCRR-6-134.php Beta thalassemia (β thalassemia) is a group of inherited blood disorders. Case report A 17-year old boy accompanied by medical support staff visited our Department for preventive and pediatric dentistry within the University Dental Center Ss.Pantelejmon in Skopje, due to a dental pain which comes from the first molar tooth(36) of the low jaw from the left side. From the accompanying documentation we saw that the boy has congenital beta thalassemia major and was admitted to the Department for Hematology within University State Hospital Mother Theresa a month ago. The boy was hospitalized in an agreed term for realization of allogeneic bone marrow transplantation, from a related donor (sister). Dental problems in patients with thalassemia are common and should not be neglected. With the introduction of stem cell transplantation from a related donor, a bright future has been opened for children with thalassemia in the Republic of North Macedonia. 04 Aug, 2021 https://www.clinsurggroup.us/articles/AHCRR-6-133.php The sequential occurrence of Immune Thrombocytopenic Purpura (ITP) and Essential Thrombocythemia (ET) has been reported in the literature on a few occasions, as these are two hematologic disorders with distinct etiologies and patients usually have contrasting clinical presentations. Our case highlights the sequential occurrence of ITP, followed by Janus kinase 2 (JAK2) (V617F)-positive ET in a 64-year-old white woman, after four years of follow-up. The pathophysiology relating to these two conditions is incompletely understood, however, JAK2(V617F) mutation has been found in all the cases reported. Early identification of JAK2(V617F) mutation in a patient with a past medical history of ITP and presenting with thrombocytosis, may lead to a prompt diagnosis of ET and timely treatment initiation. 17 Jul, 2021 https://www.clinsurggroup.us/articles/AHCRR-6-132.php Objective: Triclonal gammopathies, although considered a variant of monoclonal gammopathy of unknown significance, have been shown to be associated with other malignancies and inflammatory pathologies. There is sadly a paucity of triclonal gammopathies reported in the literature. Here, we present a case diagnosed with triclonal gammopathy/ MGUS to add to the small body of knowledge available about this rare condition. Methods: Review of the case history and laboratory investigations. Results: The case history and progression of disease of an 86 year old female diagnosed with triclonal gammopathy/ MGUS (by capillary electrophoresis and immunosubtraction), smoldering plasma cell myeloma, progressive paraproteinemia and worsening renal and hepatic functions and yet no detected bone marrow plasma cell clonality is described with relevant clinical investigations. Conclusion: Given the rarity of triclonal gammopathies, currently available research has yet to establish whether they arise from one clone or three unrelated clones of immunoglobulins. We discussed a case of triclonal gammopathy without any detected bone marrow plasma cell clonality. Increased awareness of this disorder and its associated analytical difficulties can help in the formulation of future guidelines for their analysis and treatment, as more cases are catalogued. 25 May, 2021 https://www.clinsurggroup.us/articles/AHCRR-6-131.php Background: Intracerebral Hemorrhage (ICH) is one of the most feared complications after brain tumor surgery. Postoperative hemorrhage has been described in presence of a reduction of Factor XIII (FXIII) with normal routine coagulation tests in different fields. The primary objetive was to evaluate the influence of perioperative FXIII levels on ICH after brain surgery. Methods: A prospective, observational, 18-month study was conducted at a third-level hospital in Spain. It included all consecutive adults (18 years of age or alder) operated on elective brain tumor surgery with postoperative stay in the Neurointensive Care Unit (N-ICU). Informed consent from all participants and ethical approval were obtained. Younger than 18 years of age, informed refusal, death in the OR, incomplete blood sample or non-tumoral tissue were exclusion criteria. Three blood samples evaluated FXIII levels (A-presurgical, B-postsurgical and C-24 hours after surgery). ICH, as a primary outcome variable, was defined as bleeding that generates radiological signs of intracranial hypertension either by volume or by mass effect on the routine CT scan 24 hours after surgery. The influence of tumoral data and standard coagulation were also analized. Chi-square (χ2) and Fisher’s exact tests, Mann-Whitney U and T-Tests and multiple regression were used for inferential analysis. Results: The study included 109 patients. ICH was finally confirmed in 39 of them (35,78%). Inferential analisys determined statistical association between lenght of stay in ICU (p<0,01) and male group (p0,03) with ICH. The average of FXIII was lower in patients who suffered from ICH, specially in B sample (A 71,2%, B 51,57%, C 52,14%). Statistical analisys determined FXIII deficiency (FXIIID) (<70%) after brain tumor surgery increased ICH (A p0,073, B and C p<0,01). FXIII baseline variation was also associated to ICH (FXIII A-B and A-C p<0,01, FXIII B-C 0,282). However, standard coagulation was not associated with either ICH or FXIIID. Conclusion: Acquired FXIIID (<70%) after brain tumor surgery increased ICH, so it could be considered a risk marker of hemorrhage. ICH was also associated with baseline variation, male gender and prolonged stay in ICU. Normal standard coagulation tests did not exclude FXIII disorder. Detect on time FXIIID and replacement treatment could become a therapeutic target in future studies. 22 Apr, 2021 https://www.clinsurggroup.us/articles/AHCRR-6-130.php Essential Thrombocythemia (ET) is one of seven Myeloproliferative Neoplasms (MPNs), according to the latest WHO classification [1]. 02 Feb, 2021 https://www.clinsurggroup.us/articles/AHCRR-6-129.php Bone marrow fibrosis leading to dry tap aspiration and often associated with blast crisis has previously been reported in both Chronic myeloid leukemia and Primary myelofibrosis. The similarities between these two conditions in terms of clinical presentation and morphology can really create a diagnostic dilemma. Here we present a case of Chronic myeloid leukemia in fibrosis and blast crisis in a 32 year old lady which closely resembled Primary myelofibrosis in transformation. All myeloproliferative neoplasms can undergo blast transformation. In this case, the detection of Philadelphia chromosome helped to distinguish Chronic myeloid leukemia from other myeloproliferative neoplasms. 29 Dec, 2020 https://www.clinsurggroup.us/articles/AHCRR-5-128.php A 79-year-old woman without relevant past medical history presented at Hospital Clínico UC Christus with progressive dyspnea and edema of lower extremities. Initial laboratory workup showed severe macrocytic anemia (hemoglobin, 5.7 gr/dL; MCV, 117 fL), associated with leukopenia (2800 uL), low platelet count (104000 x 103uL) and high levels of LDH (6500 UI/L). A direct visualization of blood film was performed, which evidenced macrocytosis (Figure 1A [Digital microscopy; Cellavision,×100 objective]), with ovalocytes and a few erythroblasts (Figure 1B),  hypersegmented neutrophils and eosinophils (Figure 1C-D); findings suggestive of megaloblastic anemia. 24 Nov, 2020 https://www.clinsurggroup.us/articles/AHCRR-5-127.php On March 2020, Hasharon hospital reopened as the first and solely COVID-19 hospital in Israel. For six weeks 52 positive COVID-19 patients were admitted to our ward, Corona B ward. According to previous publications, patients with coexisting hematological condition were more vulnerable to COVID-19 complications. In particular, corticosteroids treatment was reported to reduce the cytokine storm complication of COVID-19. Yet, the literature regarding corticosteroids treatment was controversial at that time. We present two positive COVID-19 hemato-oncologic patients with successful treatment with corticosteroids: a patient with active Chronic Lymphocytic Leukemia (CLL) and a patient with Hodgkin Lymphoma (HL). Epidemiological, clinical, laboratory, imaging and treatment course are discussed along with the relevant literature. 07 Nov, 2020 https://www.clinsurggroup.us/articles/AHCRR-5-126.php Chronic Myelomonocytic Leukemia (CMML) is a malignant hematopoietic stem cell disorder with clinical and pathological features of both a myeloproliferative neoplasm and myelodysplastic syndrome [1]. According to the 2016 WHO classification of hematologic malignancies it is categorized as MyeloDysplastic /Myeloproliferative Neoplasm [2]. 15 Oct, 2020 https://www.clinsurggroup.us/articles/AHCRR-5-125.php With the recent outbreak of COVID-19 the concern for airborne pathogens has increased. It is clear now that taking preventative measures such as wearing masks and social distancing are important to abate the spread and transmission of airborne pathogens. It is also equally important to identify and minimize the different sources of both direct and cross-contamination. Here we identify one source that has thus far not been considered: electronic fans used to cool the electronic components in equipment used throughout our daily lives; computers, hospital instruments, and significantly airborne samplers. Airborne samplers used to evaluate airborne pathogens must have their fan air exiting the device filtered, otherwise the device itself can be an important source as different location are sampled, moving the pathogen load from one location to another. 11 Jun, 2020 https://www.clinsurggroup.us/articles/AHCRR-5-124.php Intracranial lesions located within the region of the endolymphatic sac are typically associated with locally invasive disease rather than metastasis. 15 May, 2020 https://www.clinsurggroup.us/articles/AHCRR-5-123.php Objectives: Classic Hodgkin lymphoma (CHL) is not typically diagnosed by routine clinical flow cytometry in most laboratories. While the neoplastic Hodgkin lymphoma/ Reed Sternberg (HRS) cells in CHL may be identified by flow cytometry using special procedures, the methodology used is not common. We observed increased CD38 expression on T-cells compared to Bcells/non-T-cells in cases of CHL compared to normal samples and confirmed our observations in the context of retrospective and prospective analyses. We identified and characterized distinctive features of background non-neoplastic T cells associated with classic Hodgkin lymphoma utilizing common antibodies and analysis methods. 01 May, 2020 https://www.clinsurggroup.us/articles/AHCRR-5-122.php Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is an aggressive neoplasm which is typically CD4+, CD56+, and CD123+. 24 Jan, 2020 https://www.clinsurggroup.us/articles/AHCRR-5-121.php Dengue fever is the most rapidly spreading mosquito-borne viral disease in the world. An estimated 50 million infections per year occur across approximately 100 countries. The incidence has increased 30-fold with increasing geographic expansion with potential for further spread [1]. 20 Jul, 2019 https://www.clinsurggroup.us/articles/AHCRR-4-120.php Polycythemia Vera (PV) is a Philadelphia-negative chronic myeloproliferative neoplasm (MPN) mainly characterized by erythrocytosis. In this report we describe a case of severe cutaneous toxicity in patients with PV treated with hydroxyurea. A 72-year-old woman diagnosed with PV with V617F mutation of JAK2 performed more than 10 years before and treated with hydroxyurea plus phlebotomies and low-dose ASA for about 7 years addressed our center for the appearance of serious dermatitis at the face symptomatic for severe itch. 02 Jul, 2019 https://www.clinsurggroup.us/articles/AHCRR-4-119.php Objective: To evaluate existing relationships and differences in fatigue, depression, and hemoglobin value in individuals with Myeloproliferative Neoplasms. Methods: This study utilized the Fatigue Severity Scale, Beck Depression Inventory-II, and self-report of MPN diagnosis and latest hemoglobin value to assess the dependent variables. To promote optimal opportunity for participation in this study, potential subjects were recruited through three online-based disease-specific support groups. A total of 125 individuals consented to participate in the study. 01 Jul, 2019 https://www.clinsurggroup.us/articles/AHCRR-4-118.php Chronic myelomonocytic leukemia (CMML) is a malignant myeloid stem cell disease accompanied by dysplasia in the context of myeloproliferative disease. Peripheral cytopenias (mainly anemia and thrombocytopenia) and hepatosplenomegaly are common findings. 23 May, 2019 https://www.clinsurggroup.us/articles/AHCRR-4-117.php Malignant lymphoma can cause peripheral neuropathy through various mechanisms. We report the case of 67-year-old man with chronic motor and sensory axonal demyelinating polyneuropathy associated with anti-ganglioside GQ1b antibodies in serum and cerebrospinal fluid (CSF) as an initial presentation of peripheral T-cell lymphoma, not otherwise specified. The patient was treated with chemotherapy for T-cell lymphoma, and achieved complete remission. Motor function recovered completely and sensory function improved. Neurological improvement was concurrent with the disappearance of serum and CSF anti-ganglioside GQ1b antibodies. This is the first report of chronic demyelinating polyneuropathy associated with anti-ganglioside GQ1b antibodies in peripheral T-cell lymphoma. 09 Apr, 2019 https://www.clinsurggroup.us/articles/AHCRR-4-116.php Objective of the present study was to correlate blood grouping with “sweating in body”. ABO typing is the test to determine your blood group. In this test, you had to mix your blood with antibodies which were against the type of blood A and blood B. Blood typing is very important during pregnancy. When you had done the blood typing you have to see either Rh factor is present on the surface of your red blood cells or not. People with type A have anti B antibodies. And same in case of type B they have anti A antibodies. And there is a case of type O in which both type of antibodies i.e. A and B takes place. Total of 182 subjects participated in this study. The subjects were the students of Bahauddin Zakariya University Multan, Pakistan. ABO typing is the test to determine your blood group. In this test, you have to mix your blood with antibodies which are against the blood type A and blood type B. After this sample is check in sense that either blood cell is stick together or not. We took blood samples from 182 different subjects from their consent. These subjects were the students of Bahauddin Zakariya University Multan, Pakistan. It was concluded from the current study that B+ had maximum body sweating and AB- had minimum. 19 Feb, 2019 https://www.clinsurggroup.us/articles/AHCRR-4-115.php It is a well-known fact that multiple myeloma (MM) patients have an increased risk for thromboembolic events involving both the venous and arterial territories. The etiologies can be multifactorial, for example, activation of procoagulant factors, acquired protein C resistance, MM-specified and treatment-related factors. The risk of venous thrombosis is high when patients receive treatment with thalidomide or lenalidomide in combination with dexamethasone or multi-agent chemotherapy. Arterial thromboses occur less compared to venous thrombotic events. Nonetheless, thromboprophylaxis is important in preventing both types of thromboses. In this case study, we reveal a patient whom thrombosis occurred concurrently in both arterial and venous despite being on aspirin prophylaxis. 07 Feb, 2019 https://www.clinsurggroup.us/articles/AHCRR-4-114.php Objective of the present study was co-relating blood groping with selfie lover. A questionnaire was prepared about Selfie lover. Total numbers of students were 169 students in this research and the average age of students was 18-22 years. All the students give answer according to their blood group. Results completed according to project. We took blood sample of every student of Biotechnology. We took three spots on every slide, spot A, B and D mix antigen A, B and D respectively so we indentified blood group of every student. 29 Dec, 2018 https://www.clinsurggroup.us/articles/AHCRR-3-113.php Objective of present study was to correlate blood grouping with sleeping hours. Total subjects were 191. Add drop of water on slide sterilize your finger. Took needle and then prick upper portion of your finger make three spots on slide. Add small amount of antisera A, B and D. Mix it and after few second identify blood group. Subjects were the students of Bahauddin Zakariya University Multan, Pakistan. We asked question from them and organized data. In female, A+ blood group takes more sleep while AB- takes less sleep. In male B+ blood group take more sleep while O- and AB- take less. 21 Dec, 2018 https://www.clinsurggroup.us/articles/AHCRR-3-112.php Rivaroxaban was approved for stroke prevention for non-valvular atrial fibrillation in 2011, with added advantage of decreased risk of bleeding in comparison to coumadin, made it a good alternative for coumadin. We report a case of severe subcapsular and intrarenal hematoma associated with Rivaroxaban in an elderly male with chronic kidney disease. He presented with severe left sided flank pain, shock and acute on chronic renal failure, he was successfully resuscitated with supportive care. We aim to alert primary care physicians, hospitalists, Emergency room physicians and cardiologists regarding the likelihood of encountering similar cases as the indications of direct acting oral anticoagulants are increasing and gaining more popularity in physicians and patients as well. 19 Jun, 2018 https://www.clinsurggroup.us/articles/AHCRR-3-111.php POEMS syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. 06 Nov, 2017 https://www.clinsurggroup.us/articles/AHCRR-2-110.php Breast lymphomas are a rare sighting and image fi ndings are non-pathognomonic often mimicing different forms of invasive breast cancer. Nevertheless, multimodal imaging and subsequent histopathology are crucial for diagnosis and treatment. To draw attention to this very rare entity, we present a case of a 74 year old female patient with a tumorous mass in the left maxillary sinus. 08 Aug, 2017 https://www.clinsurggroup.us/articles/AHCRR-2-109.php Objectives: To analyze several characteristics of patients with cerebral venous sinus thrombosis in a third level hospital and to fi nd any factors that could be related to poor progress. 31 Jul, 2017 https://www.clinsurggroup.us/articles/AHCRR-2-108.php Living long term with multiple myeloma recently seems to increase the long term sequel such as second primary malignancy. 13 Apr, 2017 https://www.clinsurggroup.us/articles/AHCRR-2-107.php Upper limb DVT occurs in nearly 4-10%, but incidence increases in people that carry catheters for a long time. However thromboprophylaxis in carriers of catheters is not suggested. We report a case of upper limb DVT with pulmonary embolism with catheter migration into the heart. 11 Apr, 2017 https://www.clinsurggroup.us/articles/AHCRR-2-106.php We describe an exemplary case of inadequate health legislation and defensive medicine, regarding umbilical cord tissue collection for personal “private” use. 09 Mar, 2017 https://www.clinsurggroup.us/articles/AHCRR-2-105.php Background: Here we report a rare case of concomitant pulmonary chondroid hamartoma and follicular non Hodgkin lymphoma in a 65-year-old woman with a history of 4-month nonspecifi c symptoms like fever, sweating and weight loss. 20 Feb, 2017 https://www.clinsurggroup.us/articles/AHCRR-2-104.php Unprovoked venous thromboembolism (VTE) is defi ned as a VTE appearing in the absence of the common risk factors including cancer, surgery, hypomobility, oestrogen use or pregnancy. Around 40% of VTE patients have unprovoked VTE in real life. 30 Dec, 2016 https://www.clinsurggroup.us/articles/AHCRR-1-103.php Approximately 15% of AF patients have a history of myocardial infarction. Between 5–15% of them will require stenting at some point in their lives with the need for a triple therapy combining an oral anticoagulant, a P2Y12 Inhibitor and aspirin [1-3]. 30 Dec, 2016 https://www.clinsurggroup.us/articles/AHCRR-1-102.php Hematologists should consider the diagnosis of Gaucher disease; when they look for the cause of unexplained splenomegaly and thrombocytopenia. In countries which consanguineous marriage is prevalent, autosomal recessive disorders like Gaucher Disease may be seen frequently. 06 Dec, 2016 https://www.clinsurggroup.us/articles/AHCRR-1-101.php An 88-year-old male, with a history of diffuse abdominal discomfort and weight loss that presented a composite gastric lymphoma (CGL) expressing CD20, BCL-6 and a high cell proliferation index in diffuse large B-cell lymphoma and positive to CD30 and C15 in typical Reed-Stemberg cells forming a Classical Hodgkin´s lymphoma.