https://www.medsciencegroup.us/journals/global-journal-of-allergy A Peertechz Open Access Journal en-us 28 Jan, 2025 https://www.medsciencegroup.us/articles/Allergy-11-128.php The human microbiome plays a significant role in the development, manifestation, and mitigation of asthma and allergic diseases. Asthma, a chronic disease affecting millions worldwide, is strongly associated with immune dysfunction, particularly hyperactivation of the T-helper 2 arm of adaptive immunity. 27 Jul, 2024 https://www.medsciencegroup.us/articles/Allergy-10-127.php Lamotrigine is an anticonvulsant drug that has been widely used to treat epilepsy, as a mood stabilizer (in cases of bipolar type 1 disorder), and in the management of neuropathic pain; It is used both in monotherapy and in complementary therapy. Considered a relatively new medication, approved by the Food and Drug Administration in 1994, its benefits include a greater margin of safety compared to other anticonvulsants; However, it causes serious adverse skin reactions, such as Stevens-Johnson syndrome. Approximately 8% of patients receiving lamotrigine develop a benign maculopapular rash during the first 4 months of treatment. A case of Stevens-Johnson syndrome caused by the drug is presented and a review of the condition and the probable pathways that trigger this delayed hypersensitivity immune response is carried out. 29 Nov, 2023 https://www.medsciencegroup.us/articles/Allergy-9-126.php The study aimed to synthesize silver nanoparticles with anti-diabetic properties using Cassia fistula bark extract using a one-step biological method. The methanolic bark extract was mixed with a 1mm silver nitrate solution, and the resulting silver nanoparticles were characterized using various methods such as visual examination, UV visible spectroscopy, FTIR spectroscopy, Field Emission Scanning Electron Microscopy, in vitro Dissolution Study, Particle Size determination, and Zeta Potential determination. The green synthesis of silver nanoparticles using Cassia fistula bark extract aimed to develop a novel drug delivery system with herbal drugs to reduce side effects. The plasmon band in the silver nanoparticles was found to be 425 nm, and the FTIR study revealed a higher presence of Hydroxyl and carboxylic groups as reducing and stabilizing agents. The drug entrapment was found to be 61.5%, the particle size was 148.5 nm and the polydispersity index was 0.243. The zeta potential was measured to be -0.1 mV, indicating no stabilization of the silver nanoparticles. The FESEM analysis showed the synthesized silver nanoparticles to be spherical and oval in shape. This biological method is eco-friendly and cost-effective, making it a promising alternative to traditional chemical/stabilizing agents. 27 Dec, 2022 https://www.medsciencegroup.us/articles/Allergy-8-125.php Since the late 20th century, environmental exposure to endotoxins has been very low and type I allergic disease has increased. In addition, we have increased exposure to PM2.5 and other chemicals. Recently, there is concern that the daily use of hygiene products containing antimicrobial substances is associated with an increased prevalence of allergies. It has been noted that these antimicrobial substances may exacerbate allergies. In our study, we confirmed that intratracheal administration of aqueous mite solution as an inhaled antigen and antimicrobial substance as an aggravating chemical induced much stronger allergic bronchial asthma in mice than in mice that received intratracheal mite solution alone. Thus, allergies have been found to be exacerbated by simultaneous exposure to both environmental antigens and man-made chemicals (adjuvants). Next, we analyzed 16S rRNA of the gut microbiota of triclosan-treated mice that developed an allergy. The bacterial gene abundance of 16S rRNA of Deltaproteobacteria, Erysipelotrichi and Clostridia was increased in a dose-dependent manner in triclosan-treated mice, while Bacteroides were decreased in these mice. The composition of the gut microbiota was altered after triclosan treatment and correlated with the exacerbation of asthmatic disease in these mice. In conclusion, because triclosan exacerbated the condition of allergic asthma in mice that inhaled mite antigens and were given triclosan to drink, and this condition was associated with an increase or decrease in certain bacteria in the gut, we suspect that if allergy sufferers continue to use triclosan, they will inhale dust mites and house dust on a daily basis, which may aggravate their allergy symptoms. Overall, the overuse of antimicrobials and preservatives in current daily life risks further increasing the number of allergic patients. The authors believe that it is time to rethink this lifestyle. 16 Aug, 2021 https://www.medsciencegroup.us/articles/Allergy-7-124.php Background: Indian subcontinent has high burden of patients suffering from respiratory allergy associated with food sensitization. Immune response is different in skin and blood for allergen sensitization. Skin Prick Test (SPT) and Specific IgE (s IgE) allergen positivity is an evidence of sensitization. Both these tests (SPT & sIgE) are often used interchangeably in clinical practice of allergic disorders. In our study the concordance relevance of various tests SPT, sIgE, Total IgE, Absolute Eosinophil Count (AEC) & Serum Cortisol was investigated in 75 patients of respiratory allergy. The aeroallergens were divided into four groups (Dust mite, Pollen, Fungi, Cockroach) & 7 Foods (Milk, Soybean, Wheat, Fish, Peanut, Egg white, Yeast). Total 35 common allergens were tested by SPT. Serum Specific IgE estimation was carried out with 16 allergens (D. pteronyssinus, D. farinae, Alternaria alternata, Candida albicans, Aspergillus fumigatus, mesquite (Prosopis juliflora), common pigweed, goosefoot lamb’s quarter (Chenopodium album), cockroach and seven food allergens (milk, soybean, wheat, fish, peanut, egg white, yeast). Methods and findings: A retrospective stratified sample of 75 respiratory allergic patients within age group of 05-70 years was included in the study. Serum total IgE and specific IgE levels were estimated by using ImmunoCAP® system and SPT was done by standardized allergens (Allergo Pharma and Greer laboratories Inc.). Following results were compared to evaluate concordance/ discordance between various markers for respiratory allergy. 1. Sensitizations pattern based on Serum (16 specific IgE >1 kU/ml) with Skin prick tests Positive >4 mm wheal Size (35 aero-allergens) 2. Serum Total IgE levels >250 IU/ml with Sensitizations based on Serum (16 specific IgE >1 kU/ml) with Skin Prick Tests Positive >4 mm wheal Size (35 aero-allergens) 3. Absolute Eosinophil Count >200 cells/uL with Sensitizations based on Serum (16 specific IgE >1 kU/ml) with Skin Prick Tests Positive >4 mm wheal Size (35 aero-allergens) 4. Serum cortisol level <10>1 kU/ml) with Skin Prick Test Positive >4 mm wheal Size (35 aero-allergens). 30 Dec, 2020 https://www.medsciencegroup.us/articles/Allergy-6-123.php Allergy is a common condition that affects millions of people worldwide. It is caused by the immune system’s abnormal response to harmless substances in the environment, known as allergens. 04 Nov, 2019 https://www.medsciencegroup.us/articles/Allergy-5-122.php Background: Food allergens appear to play a role in the etiology and deteriorating of atopy in some patients, little is known about hypersensitivity to some common food additives in these patients. The purpose of this study was to identify probable sensitization to saffron, sumac and barberry in patients with atopy. 05 Oct, 2018 https://www.medsciencegroup.us/articles/Allergy-4-121.php Importance: Allergic rhinitis affects about 20% of the population worldwide. Available pharmacological treatments are helpful but not ideal in providing relief; safer and more effective treatments are needed. Objective: To evaluate the efficacy and safety of Nasapaque nasal solution vs placebo for relief or prophylactic treatment of seasonal allergic rhinitis. 18 Aug, 2017 https://www.medsciencegroup.us/Allergy/Allergy-3-120.php Plastic bronchitis is a rare disease characterized by the formation of bronchial casts that can cause partial or complete obstruction of the airway. 30 Jun, 2017 https://www.medsciencegroup.us/Allergy/Allergy-3-119.php Atopic dermatitis and allergic asthma result from amplifi ed immune response to environmental antigens, and allergic reactions from released IgE, histamine, leukotrienes and cytokines. Environmental antigens immune cells, 04 May, 2017 https://www.medsciencegroup.us/Allergy/Allergy-3-118.php Background: Cysteinyl leukotriene levels are elevated in patients with atopic dermatitis, which can lead to eosinophilic infi ltration of the gastrointestinal tract. 27 Mar, 2017 https://www.medsciencegroup.us/Allergy/Allergy-3-117.php Calendula offi cinalis is a plant belonging to the Asteraceae family. Herbal preparations from Calendula have been used topically as a natural anti-infl ammatory medicine and for the healing of wounds and leg ulcers. Although data on dermal irritation and sensitization are available, the risk of subchronic systemic toxicity following dermal application of Calendula offi cinalis preparations has not been evaluated. The threshold of toxicological concern is only based on a pragmatic risk assessment approach that gained regulatory acceptance for food 24 Feb, 2017 https://www.medsciencegroup.us/Allergy/Allergy-3-116.php Atopic dermatitis is one of the epidemically expanding non-infectious diseases in the 21 century. It poses immense challenges to both patients and physicians. With a steady growth in its incidence and prevalence, the disease carries a heavy social and economical burden. Herein we discuss the therapeutic algorithm for atopic dermatitis in accordance with the disease severity 23 Feb, 2017 https://www.medsciencegroup.us/Allergy/Allergy-3-115.php Asthma-COPD overlap syndrome (ACOS), a clinical syndrome common in routine practice, is still not fully defi ned entity characterized by features of both asthma and chronic obstructive pulmonary disease (COPD). 29 Dec, 2016 https://www.medsciencegroup.us/Allergy/Allergy-2-114.php Drugs known as Selective Serotonin Reuptake Inhibitors (SSRI) are amongst the most commonly described psychotropic drugs. These are used in the treatment of a multitude of Psychiatric and non-psychiatric conditions and are also being explored as potential immunosuppressants/immunomodulators [1]. 24 Mar, 2016 https://www.medsciencegroup.us/Allergy/Allergy-2-113.php The distribution of fish species in Jemma and Wonchit Rivers was studied from November 2012 to May 2014 based on samples collected during wet and dry seasons using gillnets of 60, 80, 100, 120 and 140 mm stretched mesh sizes. Labeobarbus intermedius, Labeobarbus nedgia, Heterobranchus longifilis, Bagrus docmak, Varicorhinus beso and Oreochromis niloticus are commercially important fish species found in both rivers of the pooled experimental fish catch. 29 Feb, 2016 https://www.medsciencegroup.us/Allergy/Allergy-2-112.php Nocturnal asthma is defined by a drop in forced expiratory volume in 1 second (FEV1) of at least 15% between bedtime and awakening in patients with clinical and physiologic evidence of asthma. Nocturnal asthma is associated with a circadian pattern in lung function, distal airway inflammation, glucocorticoid receptor affinity, pulmonary capillary blood volume, and beta-2 adrenergic receptor function may also contribute. Knowledge of these characteristics, along with an understanding of the specific therapies directed at the circadian nature of this disease, can result in significant improvements in lung function, sleep quality, and asthma related quality of life. 16 Jan, 2016 https://www.medsciencegroup.us/Allergy/Allergy-2-111.php We reported a female with a delayed-type allergic skin reaction caused by ginkgo nuts and trees. Patch tests showed positive reactions to ginkgo extracts and ursiol. The sensitized stage of her contact dermatitis might involve taking a walk or picking up gingko nuts, and the provocation stage might occur when walking along the street. 22 Dec, 2015 https://www.medsciencegroup.us/Allergy/Allergy-1-110.php There seems to be no unanimity of opinion as to the mode of transmission of allergic disease. According to some, allergy is transmitted as a simple Mendelian dominant. In direct contrast, others maintain that the findings favor a recessive mechanism. Further- more, others suggest that the condition is inherited as a “partial dominant” disorder. An additional analysis of family studies as well as data already published, failed to support either the simple dominant or recessive theory. The dominant theory does not explain why in more than half of the pedigrees both parents are normal. 11 Dec, 2015 https://www.medsciencegroup.us/Allergy/Allergy-1-109.php This survey evaluated the impact of food allergy on the allergic person's travel decision, trip organization and stay abroad. Hundred and two persons have participated. Results show that food allergy prevents 14% of respondents from travelling. Of the 81 travellers, 49% gets anxiety and 46% fear from food allergy. Difficulties related to food intake at restaurants were expressed by 67% of travellers. It is shown that allergic travellers adopt preventive behaviours and avoidance attitudes of allergenic products such as carrying their own food, reading labels, avoiding consumption of local foods, questioning about food composition. To prevent reaction after accidental ingestion, 69 travellers carry their emergency kit during travel. However, allergic accidents occurred to 30% of travellers. Food served in restaurants and homemade foods were the principal causes. 03 Oct, 2015 https://www.medsciencegroup.us/Allergy/Allergy-1-108.php Mini review article deals with the most studied group of chemical compounds – polyphenols – predominantly flavonoids in relation to their allergic immune response. There is clarified and discussed their mechanism of action as well. We emphasized on the strongest inhibitors of allergic reactions - luteolin, fisetin and apigenin, but in the second part the currently studied flavonoids have been summarized as well. 25 Sep, 2015 https://www.medsciencegroup.us/Allergy/Allergy-1-107.php Case Presentation: A 42-year-old woman, with no atopic history, has experienced two anaphylactic reactions after consuming yuzu. Skin prick tests (SPTs) were performed with juice, peel and pulp of commercially available lemon, orange, grapefruit, tangerine and yuzu, 2 cultivars of Citrus junos, 2 cultivars of Citrus reticulata, one Citrus ichangensis and food consumed during the culprit meal. 20 Aug, 2015 https://www.medsciencegroup.us/Allergy/Allergy-1-106.php The importance of diet and supplement intake in the onset and development of asthma has been advocated recently, and it may be important in the prevention and management of bronchial asthma. Long-chain n-3 polyunsaturated fatty acids (LCn3PUFAs), vitamins (Vit), choline, and probiotics may be candidates to reduce medication use and provide some protection from risk. Experimental studies of diet in bronchial asthma have demonstrated modification of pulmonary function and the immune system through mechanisms involving antioxidant effect, T-helper (Th) 2 and Th17 inhibition, tolerogenic regulatory T cell (Treg) function promotion, nuclear transcription factors and epigenetic regulation. Although studies in animal models have provided evidence of supportive effects of diet in asthma, there have been few longitudinal studies of dietary or supplement intake and asthma, and the available epidemiological data remain controversial and inconclusive. 05 Mar, 2015 https://www.medsciencegroup.us/Allergy/Allergy-1-105.php Glucocorticoid (GC)s exert anti-inflammatory effects via binding to the glucocorticoid receptor (GR) (NR3C1), targeted gene expression, and protein synthesis, which need hours before the onset of the action (transactivation). GCs also suppress inflammation by direct or indirect interaction with transcription factors, such as activator protein-1 (AP-1) and nuclear factor-κB (NF-κB) (transrepression). Recently, the non-genomic actions of GCs were discovered on recognition of its rapid onset of action within seconds to minutes. 15 Feb, 2015 https://www.medsciencegroup.us/Allergy/Allergy-1-104.php Introduction: Occupational asthma (OA) became an important public health problem worldwide in the last few decades. From two different OA types, sensitizer-induced OA accounts for approximately 90% of all OA cases. Aim of the study was to present the distribution of sensitizer-induced OA by occupation in R. Macedonia in the period 2005-2014. 10 Jan, 2015 https://www.medsciencegroup.us/Allergy/Allergy-1-103.php Investigation of water hyacinth was conducted from October 27, 2011 to November 3, 2011 by interdisciplinary expedition groups. A total of 24 sites were delineated using geographical positioning system &#40;GPS&#41; during investigation of water hyacinth incidence along the whole periphery of Lake Tana. Water hyacinth was started from Mitreha Abawarka kebele of Gondar zuria woreda specifically around at Netseba village with an estimated of 3 hectare area coverage. Highest infestation of the weed was observed at Megech River mouth with estimated area coverage of c. 80-100 hectare. Its infestation extends up to Dirma River mouth. Especial adaptation of water hyacinth on land based conditions at which soil moisture relatively high was observed around Tana woina kebele of Gondar zuria woreda adjacent lake shore side. 05 Dec, 2014 https://www.medsciencegroup.us/Allergy/Allergy-1-102.php Asthma is common chronic inflammatory disease of the airways characterised by variable and attacks of cough and breathlesness, usually precipitated by an enviromental trigger (air pollution, smoke, etc). The prevalence and severity for allergic asthma have increased markedly in the last several decades. Dysregulated expression patterns of pro- and anti inflammatory mechanisms are thought to be responsible for the development of chronic inflammation. The risk of developing asthma has a strong genetic component, with estimated heritability ranging from 35 to 85%. The mechanism of action of Omalizumab in the treatment of asthma is believed to be multifactorial. 05 Dec, 2014 https://www.medsciencegroup.us/Allergy/Allergy-1-101.php Asthma is a well known and high impact global health problem [1]. It shares, along with other prevalent entities, a number of not insignificant difficulties in the delivery of health care needs for it's control [2]. From a clinical Point of view, the use of inhaled steroid medications (Clinical Efficacy measured as: No. of asthmatics patients controlled /No. of asthmatics patients treated) have proven their worth and are the mainstay of treatment in many Published Guidelines about asthma; and deservedly so. However, from a public health point of view, the clinical effectiveness of such strategies (Clinical Effectiveness measured as: No. of asthmatics patients controlled.