https://www.cancerresgroup.us/journals/scientific-journal-of-genetics-and-gene-therapy A Peertechz Open Access Journal en-us 17 Mar, 2026 https://www.cancerresgroup.us/articles/SJGGT-12-125.php Background: Primary peritoneal carcinoma, fallopian tube cancer, and platinum-resistant epithelial ovarian cancer are aggressive cancers with few treatment choices and a dismal prognosis. In a variety of solid malignancies, immune checkpoint medications that target the programmed death receptor-1 (PD-1) have demonstrated encouraging activity. Objectives: To examine the clinical effectiveness, safety, and therapeutic implications of pembrolizumab in combination with paclitaxel, with or without bevacizumab, for platinum-resistant ovarian cancers that express programmed death-ligand 1 (PD-L1). This approval was recently made by the US Food and Drug Administration (FDA). Methods: Reviewed KEYNOTE-B96 (NCT05116189) clinical trial data, prescription information, and regulatory announcements. Progress-free survival (PFS) and overall survival (OS), as determined by the RECIST v1.1 criteria, were key effectiveness goals. Results: PFS was 8.3 months in the pembrolizumab arm and 7.2 months in the placebo arm for patients with PD-L1 combination positive score (CPS) ≥1 (HR 0.72; p = 0.0014). 18.2 months and 14.0 months, respectively, were the median OS (HR 0.76; p = 0.0053). The safety profile aligned with immune-related side effects linked to PD-1 inhibitors that have been documented before. Conclusion: The treatment of platinum-resistant ovarian tumors has advanced clinically with the approval of pembrolizumab in combination therapy. PD-L1 CPS-based biomarker-driven patient selection improves precision oncology methods and could lead to better survival rates in this high-risk group. 12 Apr, 2023 https://www.cancerresgroup.us/articles/SJGGT-9-122.php This article explores the use of exosomes in skin care and their potential for modifying epigenetic changes in fibroblasts and other immune regulatory cells of the skin. Exosomes are nanosized extracellular vesicles that play a vital role in intercellular communication by transporting various biomolecules such as proteins, lipids, and nucleic acids between cells. They are released by skin cells and contain various molecules that are essential for skin health, such as growth factors, cytokines, and extracellular matrix proteins. Recent studies have shown that exosomes can modify epigenetic changes in skin cells, particularly histones, and they have the potential to be used as a therapeutic agent in various skin disorders. This article discusses the use of exosomes in skin care and their potential for modulating epigenetic changes in skin cells in response to environmental factors, with a focus on histone modifications. 28 Dec, 2022 https://www.cancerresgroup.us/articles/SJGGT-8-121.php Human populations can be characterized by their corresponding phenotypic profiles which do not necessarily align. These differences are not our points of strength in building harmonious societies and establishing a sustainable world order; it is therefore desirable to seek a pathway to resolve them. This article reflects on genetics as the most profound source of our differences and introduces Voluntary Selection as a means of acquiring genetic qualities and resolving the imbalance in their possession by different populations. Voluntary Selection is a healthcare program allowing for voluntarily involving the reproductive cells of another individual than the parents to conceive a child at the discretion of a parent population. Genetic qualities in this context are desired phenotypes as perceived by each population. The article then presents a computational approach through which thoughtful decisions about the design of a program can be made. These methods are applied to a pedigree data set of adult heights and the results are used to demonstrate the influence of the program design and the significance of its outcomes. 06 Jan, 2022 https://www.cancerresgroup.us/articles/SJGGT-8-120.php Background: New coronavirus disease is considered one of the most widely spreading viral infections all over the world. Increased numbers of severe COVID-19 cases are growing up. Severe cases require ICU mechanical ventilation and hence anesthesia requirement. Aim: Reviewing of different genetic polymorphisms which might affect patient clinical response, safety and tolerability to different types of anesthesia used in severe COVID-19 patients requiring mechanical ventilation. Main body of the abstract: Severity of COVID-19 infection resulted from cytokine storm that leads to Acute Respiratory Distress Syndrome (ARDS) contribute in ICUs mechanical ventilation and anesthesia. Genetic polymorphisms showed to contribute in wide variation in anesthetic responses. Different polymorphic genes of RYR1, CACNA1S, MTHFR, OPRM1, ABCB1, CYP2B6 and others, play a main role in such variations. Different types of anesthesia as sevoflurane, midazolam, suxamethonium, nitrous oxide, fentanyl, and propofol showed altered pharmacokinetics and/or dynamics leading to a lack of anesthetic effect and incidence of life-threatening adverse effects as malignant hyperthermia, myocardial infarction, dyspnea, and others. Short conclusion: Genetic screening is a serious step to take into consideration to identify genetic polymorphic types that may alter the anesthetic effect in ICUs ventilation. Besides, it will avoid possible adverse effects and different sedation response variations. Sevoflurane, Fentanyl, and propofol can be taken into consideration as a safe choice for use in ICUs taking into consideration genetic polymorphic variants. 04 Dec, 2021 https://www.cancerresgroup.us/articles/SJGGT-7-119.php Vitis vinifera ‘Guifeimeigui’ is a diploid table grape, a Eurasian species. This research first reported the complete chloroplast (cp) genome of Vitis vinifera ‘Guifeimeigui’. The size of the complete cp genome is 160,928 bp and its GC content is 37.38%, including a pair of inverted repeats (26,353 bp each) separated by large (89,150 bp) and small (19,072 bp) single-copy regions. It encodes 85 genes, including 40 protein coding genes, 37 transfer RNA genes (tRNA), and 8 ribosomal RNA genes (rRNA). The Maximum Likelihood (ML) phylogenetic tree demonstrated that Vitis vinifera ‘Guifeimeigui’ is close to Vitis vinifera. 29 Aug, 2020 https://www.cancerresgroup.us/articles/SJGGT-6-118.php New corona virus disease (COVID-19) is a recent worldwide pandemic occurred as a result of SARS-CoV-2 virus, where, it spreads mainly through large respiratory droplets, and probability of other routes of transmission do exist, due to the suspicion of the viral abundance in feces and urine of affected individuals [1]. The transfer and transmission of COVID-19 is high and occurs via respiratory secretions, where, the virus invades the body through the inner wall cells of upper respiratory tract causing severe injury of the lungs, affecting its performance, and consequently respiration efficiency [2]. Transmission between individuals occurs mainly through direct contact or droplets spread by sneezing or coughing from carrier individual which is accompanied by binding of SARS-COV spikes to the ACE2 cellular receptor expressed by lung epithelial cells which is the first step of the viral infection followed by fusion with the cell membrane. Concerning the clinical findings of COVID-19 infection, it was found that there is an increased levels of plasma pro-inflammatory cytokines like IL1-β, IL1RA, IL7, IL8, IL9, IL10, TNFα, leucopenia, elevated C-reactive protein, elevated D-dimer, and high ESR [3]. However, most of the infected patients showed a mild clinical presentation of the disease, while others have developed severe signs and symptoms characterized by respiratory compromise [4]. It is well-known that the genome is the human DNA, his /her genes and their expressions which in turn give the different specific characteristic of the human being. Moreover, the thousands of genetic variations among people are reported for each allele which is called Snips (SNPs). In fact, diploid people with two different alleles types known as (Heterozygous) are more likely to develop polymorphism, than those with the same allele type (Homozygous), especially in those environments rich with pathogens. It is assumed that different Human Leukocyte Antigen (HLA) molecules are supporting potential to present peptides derived from pathogens are due to T-lymphocytes, and so triggering an immune reaction. New corona virus disease (COVID-19) is a recent worldwide pandemic occurred as a result of SARS-CoV-2 virus, where, it spreads mainly through large respiratory droplets, and probability of other routes of transmission do exist, due to the suspicion of the viral abundance in feces and urine of affected individuals [1]. The transfer and transmission of COVID-19 is high and occurs via respiratory secretions, where, the virus invades the body through the inner wall cells of upper respiratory tract causing severe injury of the lungs, affecting its performance, and consequently respiration efficiency [2]. Transmission between individuals occurs mainly through direct contact or droplets spread by sneezing or coughing from carrier individual which is accompanied by binding of SARS-COV spikes to the ACE2 cellular receptor expressed by lung epithelial cells which is the first step of the viral infection followed by fusion with the cell membrane. Concerning the clinical findings of COVID-19 infection, it was found that there is an increased levels of plasma pro-inflammatory cytokines like IL1-β, IL1RA, IL7, IL8, IL9, IL10, TNFα, leucopenia, elevated C-reactive protein, elevated D-dimer, and high ESR [3]. However, most of the infected patients showed a mild clinical presentation of the disease, while others have developed severe signs and symptoms characterized by respiratory compromise [4]. It is well-known that the genome is the human DNA, his /her genes and their expressions which in turn give the different specific characteristic of the human being. Moreover, the thousands of genetic variations among people are reported for each allele which is called Snips (SNPs). In fact, diploid people with two different alleles types known as (Heterozygous) are more likely to develop polymorphism, than those with the same allele type (Homozygous), especially in those environments rich with pathogens. It is assumed that different Human Leukocyte Antigen (HLA) molecules are supporting potential to present peptides derived from pathogens are due to T-lymphocytes, and so triggering an immune reaction. 12 Sep, 2019 https://www.cancerresgroup.us/articles/SJGGT-5-117.php Introduction: The tuberous sclerosis complex is a multisystemic disease of autosomal dominant etiology, not pretty common in Latin America. It is caused by the mutation of the TSC1 and TSC2 genes which is characterized by uncontrolled production of Hamartomas in diverse organs and systems. However, some patients could present asymptomatic characteristics whereas other could experience fatal symptoms. 28 Jul, 2018 https://www.cancerresgroup.us/articles/SJGGT-4-116.php Caveolin-1 is the essential structural formation for lipid raft formation. It has been ascribed to several disease processes in humans due to its ubiquitous distribution. Patients with chronic kidney disease suffer great morbidity and mortality where manipulation of caveolin-1 could lead to new potential therapeutic targets in this patient group. This review highlights caveolin-1 structure, signalling and provides examples of studies of caveolin-1 single nucleotide polymorphism in chronic kidney disease. 28 Jul, 2018 https://www.cancerresgroup.us/articles/SJGGT-4-115.php This short review describes the strategies employed for investigating genetic variation in chronic kidney disease as well as highlighting potential shortfalls that should be overcome in future studies. 11 Jul, 2018 https://www.cancerresgroup.us/articles/SJGGT-4-114.php Lung cancer is a leading cause of cancer deaths world-wide, with the carcinogens in tobacco smoke playing a major etiologic role. Genetic changes responsible for carcinogenesis include activation of proto-oncogenes and inactivation of tumor suppressor genes. Tumor suppressor gene inactivation is contributed to, in part, by loss of chromosomal DNA. While cytogenetic findings in small cell neuroendocrine lung carcinoma are complex, 5q deletion is among the most frequently identified [1,2]. 15 Feb, 2018 https://www.cancerresgroup.us/articles/SJGGT-4-113.php The U.S. Food and Drug Administration approved use of Lynparza (olaparib tablets) treat certain types of breast cancer that have spread (metastasized) and whose tumors have a specific inherited (germline) genetic mutation, making it the first drug in its class (PARP inhibitor) approved to treat breast cancer. 11 Nov, 2017 https://www.cancerresgroup.us/articles/SJGGT-3-112.php Nigeria is known to have the highest twining rate in the world. In this report, we present a case of a woman MS, 32 years old, Gravida4, Para3 (3alive), who had caesarian section for conjoined twin (thoracopagus) and malformed triplet on 26/3/2015 at 21 weeks of gestation. 30 Dec, 2016 https://www.cancerresgroup.us/articles/SJGGT-2-111.php Morphological, phytochemical and genetic differences were studied to evaluate the level and distribution of diversity among thirteen genotypes of Mentha using both agro-morphological traits and ISSR markers. 30 Dec, 2016 https://www.cancerresgroup.us/articles/SJGGT-2-110.php Background: Schizophrenia is a polygenic mental disorder with about 80% heritability. Growing evidence indicated that synaptic dysfunctions contribute to SCZ etiopathogenesis. 08 Jul, 2016 https://www.cancerresgroup.us/articles/SJGGT-2-109.php Mutations in the transmembrane channel-like gene1 (TMC1) are known to cause autosomal dominant and recessive forms of nonsyndromic hearing loss DFNA36 and DFNB7/11, respectively. Here, we characterized a 5-year old girl with severe sensorineural hearing loss 19 Jan, 2016 https://www.cancerresgroup.us/articles/SJGGT-2-108.php Background: Artemisia herba alba is an aromatic species very rich in secondary metabolites that can be used in traditional medicine. 07 Jan, 2016 https://www.cancerresgroup.us/articles/SJGGT-2-107.php Gastrointestinal stromal tumors (GISTs) are rare sporadic tumors that typically occur late in life, although they are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs are believed to originate from the Interstitial Cells of Cajal (ICC), a group of cells identified in the wall of the organs of the gastrointestinal tract, which act as a pace-maker for peristalsis and gut movements. However, familial and pediatric cases have also been reported. 30 Dec, 2015 https://www.cancerresgroup.us/articles/SJGGT-1-106.php Background: Schizophrenia (SCZ) is a multifactorial mental disease. Whereas complex interplay of genes and environment contributes to the SCZ, the disorder has still unclear biological background. Growing amount of evidence showed that synaptic dysfunctions are contributed to SCZ etiopathogenesis. 23 Nov, 2015 https://www.cancerresgroup.us/articles/SJGGT-1-105.php Background: The origin of atopic disease is poly factorial and the development of atopic manifestations appears to be linked to interactions between genetic and environmental factors. Such data seem to focus attention on the rising prevalence rates of atopic dermatitis, a common debilitating skin codition in infants and young children. They also often have asthma and/or allergic rhinitis. 10 Aug, 2015 https://www.cancerresgroup.us/articles/SJGGT-1-104.php Background: Allergic asthma and rhinitis, atopic dermatitis, urticaria and food allergy are genetic diseases of infants and children. Several investigators have provided evidence for a genetic localization for atopy. Babies of atopic parents are at high risk of developing atopic diseases, however the phenotypic expression of such diseases varies widely, being very mild in some infants and children, severe and frustrating in many, even life-threatening in others, being also common, disabilitating, and chronic. 07 May, 2015 https://www.cancerresgroup.us/Genetics-Gene-Therapy/SJGGT-1-103.php Transposable elements (TEs) include a wide range of DNA sequences that can change positions in the genome. The accessibility of whole fungal genome sequences and analysis of TEs demonstrate the important role they play in genome evolution of fungi species. TE activity is a primary mechanism for high fitness, plasticity and adaptability in certain species of pathogenic fungi. 27 Mar, 2014 https://www.cancerresgroup.us/Genetics-Gene-Therapy/SJGGT-1-101.php Antisense oligonucleotides (oligos) have been evaluated for treating prostate cancer in both in vivo and in vitro models. Although most oligos contain a single mRNA binding site, our laboratory evaluates bi-specific oligos directed towards two proteins. This study evaluates the growth inhibition in vitro of the LNCaP cell line employing mono- and bi-specific oligos directed against BCL-2 [the second binding site was directed against the epidermal growth factor receptor (EGFR)].