https://www.reprodgroup.us/journals/studies-on-stem-cells-research-and-therapy A Peertechz Open Access Journal en-us 07 Apr, 2023 https://www.reprodgroup.us/articles/SSCRT-9-120.php Knowledge regarding the spatiotemporal distribution of cells that express pluripotent and Progenitor-Neural Stem Cell Markers (PNSC) is vital for understanding their role in various stages of embryonic brain development. However, there are few data that connect these markers’ expression with the developmental stage in the mouse brain. We investigated the expression of pluripotent cell markers (Oct4, Nanog, and Sox2) and PNSC markers (Sox 1; nestin, vimentin, GFAP) in mice brains on Embryonic (E) days E9.5, E12.5, E15.5 and E18.5 and in the mature adult brain. We observed the expression of all studied markers in rostral and caudal neuropores at E9.5. The cells at E12.5 in primary brain vesicles showed only expression of four markers: Oct4, Sox2, vimentin and nestin. In addition, hindbrain cells express Sox1 and midbrain – Fragilis. The Ventricular Zone (VZ) at E15.5 and E18.5 shared the expression of Oct 4, Sox 2, Sox1, nestin, and GFAP, besides at E18.5 VZ expressed Fragilis. The olfactory bulb (OB) at E18.5 showed the expression of Sox2, Nanog, Fragilis, Nestin, and GFAP. In the adult brain, the sub-VZ (SVZ) showed expression of all studied markers, but not for Sox2 and Nanog; OB is positive for Nestin only, while cerebellum for Sox1 and Sox2. Neuropores in embryonic and the Subventricular Zone (SVZ) in adult brains express the most considerable number of studied markers, suggesting less cell specification. SVZ is a stem cell niche in the adult brain. Oct4, Sox2 and Nestin seem indispensable during brain development and in the adult brain in mice. 17 Jun, 2021 https://www.reprodgroup.us/articles/SSCRT-7-118.php In recent past, several research papers mentioned that stem cells can cure ailments of even serious nature whether acute or chronic in humans and also in other animals. Basic and clinical research accomplished during the last few years on embryonic, fetal, amniotic, umbilical cord blood, and adult stem cells has constituted a revolution in regenerative medicine and cancer therapies by providing the possibility of generating multiple therapeutically useful cell types. These new cells could be used for treating numerous genetic and degenerative disorders. Among them, age-related functional defects, hematopoietic and immune system disorders, heart failures, chronic liver injuries, diabetes, Parkinson’s and Alzheimer’s diseases, arthritis, and muscular, skin, lung, eye, and digestive disorders as well as aggressive and recurrent cancers could be successfully treated by stem cell-based therapies [1-5]. 05 May, 2021 https://www.reprodgroup.us/articles/SSCRT-7-117.php Diabetes-related complications affect all body organ systems, including the penis. Diabetes-induced erectile dysfunction (ED) is caused by neuropathy of the penile nerves and vasculopathy of the smooth muscle and endothelium corpus cavernosum. To present an overview of Mesenchymal Stem Cell (MSC) research in diabetic animal models of ED, focusing on the function, signaling, and niches that have a prominent role in the regeneration of cavernosal cells and restoration of penile tissues. We highlight common erectile pathologies caused by diabetes and review relevant preclinical trials. We also discuss paracrine mechanisms of various MSC therapies involved in the repair of endothelial cells and cavernous nerves in these diabetic models. A PubMed search was performed, with dates ranging from inception until November 20, 2019. This review provides a comprehensive evaluation of the various strategies that have been investigated for improving MSC delivery methods, through preclinical literature and published clinical trials regarding ED in men with diabetes. MSC-type applications have been beneficial to erectile function in diabetic models of ED. This review examines the progress and remaining challenges in diabetes-related SC research regarding ED. Moving forward, it is only with a combined effort of basic biology and translational work that the potential of MSC-based therapies in diabetes can be realized. 27 May, 2020 https://www.reprodgroup.us/articles/SSCRT-6-116.php We read with interest the article entitled “Preliminary epidemiological analysis of suspected cases of corona infection in Libya” 11 Apr, 2020 https://www.reprodgroup.us/articles/SSCRT-6-115.php Mesenchymal Stem cells (MSCs) has fascinating immunomodulatory effect in vitro and in vivo. This effect has been documented by interesting researches worldwide. However the protocols of MSCs culture are different. This difference is translated on different results regarding the mediators as well as on potency of immunomodulatory effect in both vitro and in vivo. In this article we will analyze and discussing the effect of culture environment on MSC immunomodulatory effect. 28 Feb, 2020 https://www.reprodgroup.us/articles/SSCRT-6-114.php Back ground: High fat diet associated obesity associating losing of body organs structure and function is of important public health problem. The heart and lungs represent the main organs of supplying oxygen, nutrients and nutritive molecules necessary for the body function. Little of work is concerned with higher fat diet associated myocardial and lung damage. Also, the bovine whey is rich in micronutrients with biological and medicinal activity. The present study aimed to illustrate the role of whey in ameliorating the damaged effects of higher fat diet on both heart and lung. 27 Dec, 2019 https://www.reprodgroup.us/articles/SSCRT-5-113.php Back ground: Diabetes Mellitus is a public health problem associated with increased maternal blood sugar level and impair insulin secretion leading to complication of pregnancy and retarded placental development. Maternal diabetes developed premature term and mortalities of their child. The alterations of placental spiral artery during the progress of diabetes paid attention and little of work is concerned with this public health problem. The traditional increase of phytotherapy especially pomegranate peel extract and bee venom therapy encourage author to carry out this study in spiral artery of placenta at 14days of pregnancy in order to clarify the best choice of improvement the histological picture of the spiral artery. 03 Aug, 2019 https://www.reprodgroup.us/articles/SSCRT-5-112.php Background: Our objective in this study is to compare the outcomes of patients with multiple myeloma (MM) over 65 years of age who had autologous hematopoietic stem cell transplantation (AHSCT) with the outcomes of patients under 65 years of age. 01 Apr, 2017 https://www.reprodgroup.us/articles/SSCRT-3-111.php Delivery of biologically active recombinant proteins using cell-penetrating peptides is a useful tool for transduction of molecular cargo into cells. 31 Dec, 2016 https://www.reprodgroup.us/articles/SSCRT-3-110.php Aim: To compare the results of fl uorine-18 (¹8F) fl uorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and contrast enhanced computed tomography (ceCT) in the assessment of renal cell carcinoma (RCC) recurrences when ceCT had suspected lesions for local recurrence and/or distant metastases. 29 Dec, 2016 https://www.reprodgroup.us/articles/SSCRT-2-109.php Objective: Human amniotic fluid stem cells (HAFSCs) derived from human amniotic fluid during parturition are of good source in regenerative medicine for development to either adipocyte, chondrogenic or osteogenic cells. 29 Dec, 2016 https://www.reprodgroup.us/articles/SSCRT-2-108.php Objective: Lipoaspiration of human breast fats are important source of adipocyte stem cells (hAMSCs) which play a great role in regenerative medicine. The present study illustrates its capability of its transformation and characterization of adipocyte, osteogenic or chondrogenic cells. 13 Dec, 2016 https://www.reprodgroup.us/articles/SSCRT-2-107.php A new device has been designed, developed and tested to improve the capacity of vascular drug and stem cell delivery. The device consists of a catheter with a multitude of small lumens (instead of a large central channel lumen). 29 Nov, 2016 https://www.reprodgroup.us/articles/SSCRT-2-106.php Objective: Bone marrow-derived circulating endothelial cells (EPCs) may migrate in ischemia zone, to stimulate resident progenitor cells to proliferation, differentiation and migration in a damage zone, and reduce an ischemia zone through formation of new vessels. 31 Dec, 2015 https://www.reprodgroup.us/articles/SSCRT-1-105.php Stem cells are undifferentiated biological cells that able to maintain undifferentiated state through cell division and give rise to any mature cell type. They are almost divided into embryonic (ESC) and adult stem cells (ASC). ASCs have lineage restriction in compare to ESCs which they cannot differentiate into all 3 layers (ectoderm, mesoderm and endoderm) [1,2]. 31 Dec, 2015 https://www.reprodgroup.us/articles/SSCRT-1-104.php Stem cells have emerged in the health area as a promise for the healing of damaged tissues and replacement of organs. With their capacity of self-renewal and clonogenity, as well as their ability to develop into many different cell types in the body, their potential seems to be unlimited, serving as a kind of cell stock for any cellular need in the human body. Nevertheless, their potential for odontology also seems to be promising for the simple possibility of tooth reconstruction and the reestablishment of shape and function. 08 Dec, 2015 https://www.reprodgroup.us/articles/SSCRT-1-103.php Despite considerable advances in the treatment for systemic lupus erythematosus (SLE), there is still an unmet need to develop novel therapeutic approaches with improved efficacy and lower side effects. Here we explore human umbilical cord-derived mesenchymal stem cells (hUCMSCs) as a promising treatment for SLE induced by concanavalin A-activated spleno-lymphocyte in BALB/c mice. 24 Aug, 2015 https://www.reprodgroup.us/Stem-Cell-Biology-Transplantation/SSCRT-1-102.php Aging-related neurodegenerative disorders mainly include Alzheimer’s disease (AD) and Parkinson’s disease (PD). AD is the most common form of dementia, which is one of the major causes of disability and dependency in the elderly. Since the pathologic characteristics of AD are beta-amyloid (Abeta) plaques and neurofibrillary tangles (NFT) [1], depleting Abeta should be a useful therapy for AD. 30 Mar, 2015 https://www.reprodgroup.us/Stem-Cell-Biology-Transplantation/SSCRT-1-101.php Epigenetic alternations are not associated with any changing the base sequence of DNA, but are closely related to phenome together with genome [1]. Most of them are determined differently under various external and internal influences and, even if abnormal, memorized over individual life